Oleic acid reduces oxidative stress in rat brain induced by some anticancer drugs.

Autor: Calderón Guzmán D; Laboratory of Neurosciences, Instituto Nacional de Pediatria (INP), CP 04530, Mexico City, Mexico., Juárez Olguín H; Laboratory of Pharmacology, INP. and Dept of Pharmacology, Faculty of Medicine, Universidad Nacional Autónoma de Mexico, CP 04530, Mexico. Electronic address: juarezol@yahoo.com., Osnaya Brizuela N; Laboratory of Neurosciences, Instituto Nacional de Pediatria (INP), CP 04530, Mexico City, Mexico., Ortíz Herrera M; Laboratory of Experimental Bacteriology, INP, Mexico., Trujillo Jimenez F; Laboratory of Pharmacology, INP. and Dept of Pharmacology, Faculty of Medicine, Universidad Nacional Autónoma de Mexico, CP 04530, Mexico., Valenzuela Peraza A; Laboratory of Neurosciences, Instituto Nacional de Pediatria (INP), CP 04530, Mexico City, Mexico., Labra Ruiz N; Laboratory of Neurosciences, Instituto Nacional de Pediatria (INP), CP 04530, Mexico City, Mexico., Santamaria Del Angel D; Laboratory of Neurosciences, Instituto Nacional de Pediatria (INP), CP 04530, Mexico City, Mexico., Barragán Mejía G; Laboratory of Experimental Bacteriology, INP, Mexico.
Jazyk: angličtina
Zdroj: Chemico-biological interactions [Chem Biol Interact] 2024 Aug 01; Vol. 398, pp. 111086. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.cbi.2024.111086
Abstrakt: Oleic acid (OA) is a monounsaturated compound with many health-benefitting properties such as obesity prevention, increased insulin sensitivity, antihypertensive and immune-boosting properties, etc. The aim of this study was to analyze the effect of oleic acid (OA) and some anticancer drugs against oxidative damage induced by nitropropionic acid (NPA) in rat brain. Six groups of Wistar rats were treated as follows: Group 1, (control); group 2, OA; group 3, NPA + OA; group 4, cyclophosphamide (CPP) + OA; group 5, daunorubicin (DRB) + OA; and group 6, dexrazoxane (DXZ) + OA. All compounds were administered intraperitoneally route, every 24 h for 5 days. Their brains were extracted to measure lipoperoxidation (TBARS), H 2 O 2 , Ca +2 , Mg +2 ATPase activity, glutathione (GSH) and dopamine. Glucose, hemoglobin and triglycerides were measured in blood. In cortex GSH increased in all groups, except in group 2, the group 4 showed the highest increase of this biomarker. TBARS decrease, and dopamine increase in all regions of groups 4, 5 and 6. H 2 O 2 increased only in cerebellum/medulla oblongata of group 5 and 6. ATPase expression decreased in striatum of group 4. Glucose increased in group 6, and hemoglobin increased in groups 4 and 5. These results suggest that the increase of dopamine and the antioxidant effect of oleic acid administration during treatment with oncologic agents could result in less brain injury.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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