Tumor inflammatory microenvironment contribution to survival in resected upstaged adenocarcinomas.

Autor: Bonis A; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy. Electronic address: alessandro.bonis@aopd.veneto.it., Verzeletti V; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Lunardi F; Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health- DSCTV, University of Padova, 35121, Padova, Italy., Lione L; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Cannone G; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Faccioli E; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Mammana M; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Nicotra S; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Calabrese F; Pathology Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health- DSCTV, University of Padova, 35121, Padova, Italy., Dell'Amore A; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy., Rea F; Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health - DSCTV, University of Padova, 35128, Italy.
Jazyk: angličtina
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2024 Jul; Vol. 50 (7), pp. 108444. Date of Electronic Publication: 2024 May 28.
DOI: 10.1016/j.ejso.2024.108444
Abstrakt: Introduction: Tumor Inflammatory microenvironment (TIME) encompasses several immune pathways modulating cancer development and escape that are not entirely uncoded. The results achieved with immunotherapy elicited the scientific debate on TIME also in non-small cell lung cancer (NSCLC). We aimed to investigate whether TIME (in terms of PD-L1 expression and/or Tumor Infiltrating Lymphocytes - TILs) played a separate role in terms of survival (OS) in resected upstaged lung adenocarcinomas (ADCs), excluding other perioperative variables as confounders.
Materials and Methods: This retrospective study included 50 patients with a clinically resectable lung ADC, undergoing surgery (lobectomy or segmentectomy) at the Thoracic Unit of Padova University Hospital between 2016 and 2022 and receiving an unexpected pathological upstaging (IIB or higher).
Results: Despite microscopical variables increasing from IIB to IIIB, survival was not significantly related to them. OS was better in TIME-active patients (defined as the presence of positive PD-L1 and/or TILs>10 %) than double negatives (PD-L1-/TILs-) (p = 0.01). In IIB or higher ADCs, TIME-active patients showed an improved survival compared to double negatives, merging the current TIME theories.
Conclusion: TIME seems to be associated with survival independently from other microscopical parameter, even in case of resected upstaged adenocarcinomas.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.)
Databáze: MEDLINE
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