Design of a new porphyrin-based compound and investigation of its photosensitive properties for antibacterial photodynamic therapy.

Autor: Nur Kertmen Kurtar S; Material Science and Engineering Department, Kahramanmaras Sutcu Imam University, Kahramanmaras 46050, Türkiye. Electronic address: sedanurkertmen8@gmail.com., Kertmen M; Occupational Health and Safety Department, Siirt University, Siirt 56100, Türkiye., Kose M; Chemistry Department, Science Faculty, Kahramanmaras Sutcu Imam University, Kahramanmaras 46050, Türkiye. Electronic address: muhammetkose@ksu.edu.tr.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Oct 15; Vol. 319, pp. 124529. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.saa.2024.124529
Abstrakt: Considering the increasing number of pathogens resistant to commonly used antibiotics as well as antiseptics, there is an urgent need for antimicrobial approaches that can effectively inactivate pathogens without the risk of establishing resistance. An alternative approach in this context is antibacterial photodynamic therapy (APDT). APDT is a process that involves bacterial cell death using appropriate wavelength light energy and photosensitizer and causes the production of reactive oxygen species inside or outside the microbial cell depending on the penetration of light energy. In our study, a new porphyrin compound 4,4'-methylenebis(2-((E)-((4-(10,15,20-triphenylporphyrin-5-yl)phenyl)imino)methyl)phenol) (SP) was designed and synthesized as photosensitizer and its structure was clarified by NMR ( 13 C and 1 H) and mass determination method. Photophysical and photochemical properties were examined in detail using different methods. Singlet oxygen quantum yields were obtained as 0.48 and 0.59 by direct and indirect methods, respectively. Antibacterial activity studies have been conducted within the scope of biological activity and promising results have been obtained under LED light (500-700 nm, 265 V, 1500 LM), contributing to the antibacterial photodynamic therapy literature.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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