Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability.

Autor: Mamidi N; Wisconsin Center for NanoBioSystems, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, 53705, USA.; Department of Chemistry and Nanotechnology, The School of Engineering and Science, Tecnologico de Monterrey, Nuevo Leon, Monterrey, 64849, Mexico., De Silva FF; Department of Chemistry and Nanotechnology, The School of Engineering and Science, Tecnologico de Monterrey, Nuevo Leon, Monterrey, 64849, Mexico., Vacas AB; Department of Chemistry and Nanotechnology, The School of Engineering and Science, Tecnologico de Monterrey, Nuevo Leon, Monterrey, 64849, Mexico., Gutiérrez Gómez JA; Department of Chemistry and Nanotechnology, The School of Engineering and Science, Tecnologico de Monterrey, Nuevo Leon, Monterrey, 64849, Mexico., Montes Goo NY; Department of Chemistry and Nanotechnology, The School of Engineering and Science, Tecnologico de Monterrey, Nuevo Leon, Monterrey, 64849, Mexico., Mendoza DR; Department of Chemistry and Nanotechnology, The School of Engineering and Science, Tecnologico de Monterrey, Nuevo Leon, Monterrey, 64849, Mexico., Reis RL; 3Bs Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Barco, Guimarães, 4805-017, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, Portugal., Kundu SC; 3Bs Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, University of Minho, Barco, Guimarães, 4805-017, Portugal.; ICVS/3B's-PT Government Associate Laboratory, Braga, Guimarães, Portugal.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Oct; Vol. 13 (27), pp. e2401195. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1002/adhm.202401195
Abstrakt: Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein-based hydrogels mimic the extracellular matrix, promoting cell adhesion. Further enhancing cell proliferation within these scaffolds are matrix-metalloproteinase-triggered amino acid motifs. Integration of cell-friendly modules like peptides and proteins expands hydrogel functionality. These exceptional properties position hydrogels for diverse applications, including biomedicine, biosensors, environmental remediation, and the food industry. Despite significant progress, there is ongoing research to optimize hydrogels for biomedical and environmental applications further. Engineering novel hydrogels with favorable characteristics is crucial for regulating tissue architecture and facilitating ecological remediation. This review explores the synthesis, physicochemical properties, and biological implications of various hydrogel types and their extensive applications in biomedicine and environmental sectors. It elaborates on their potential applications, bridging the gap between advancements in the healthcare sector and solutions for environmental issues.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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