Beyond weakness: Exploring intramuscular fat and quadriceps atrophy in ACLR recovery.

Autor: White MS; School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA., Ogier AC; Department of Diagnostic and Interventional Radiology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland., Chenevert TL; Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA., Zucker E; School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA., Stoneback L; School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA., Michel CP; CNRS, CRMBM, Aix-Marseille Université, Marseille, France., Palmieri-Smith RM; School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA., Lepley LK; School of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.
Jazyk: angličtina
Zdroj: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2024 Nov; Vol. 42 (11), pp. 2485-2494. Date of Electronic Publication: 2024 Jun 01.
DOI: 10.1002/jor.25910
Abstrakt: Muscle weakness following anterior cruciate ligament reconstruction (ACLR) increases the risk of posttraumatic osteoarthritis (OA). However, focusing solely on muscle weakness overlooks other aspects like muscle composition, which could hinder strength recovery. Intramuscular fat is a non-contractile element linked to joint degeneration in idiopathic OA, but its role post-ACLR has not been thoroughly investigated. To bridge this gap, we aimed to characterize quadriceps volume and intramuscular fat in participants with ACLR (male/female = 15/9, age = 22.8 ± 3.6 years, body mass index [BMI] = 23.2 ± 1.9, time since surgery = 3.3 ± 0.9 years) and in controls (male/female = 14/10, age = 22.0 ± 3.1 years, BMI = 23.3 ± 2.6) while also exploring the associations between intramuscular fat and muscle volume with isometric strength. Linear mixed effects models assessed (I) muscle volume, (II) intramuscular fat, and (III) strength between limbs (ACLR vs. contralateral vs. control). Regression analyses were run to determine if intramuscular fat or volume were associated with quadriceps strength. The ACLR limb was 8%-11% smaller than the contralateral limb (p < 0.05). No between-limb differences in intramuscular fat were observed (p = 0.091-0.997). Muscle volume but not intramuscular fat was associated with strength in the ACLR and control limbs (p < 0.001-0.002). We demonstrate that intramuscular fat does not appear to be an additional source of quadriceps dysfunction following ACLR and that muscle size only explains some of the variance in muscle strength.
(© 2024 Orthopaedic Research Society.)
Databáze: MEDLINE
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