Mosquitocidal effect of ivermectin-treated nettings and sprayed walls on Anopheles gambiae s.s.

Autor: Hamid-Adiamoh M; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia. majidah.hamid-adiamoh@lshtm.ac.uk., Muhammad AK; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Assogba BS; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Soumare HM; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Jadama L; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Diallo M; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., D'Alessandro U; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Ousmane Ndiath M; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Erhart A; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia., Amambua-Ngwa A; Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, Gambia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Jun 01; Vol. 14 (1), pp. 12620. Date of Electronic Publication: 2024 Jun 01.
DOI: 10.1038/s41598-024-63389-x
Abstrakt: Ivermectin (IVM) has been proposed as a new tool for malaria control as it is toxic on vectors feeding on treated humans or cattle. Nevertheless, IVM may have a direct mosquitocidal effect when applied on bed nets or sprayed walls. The potential for IVM application as a new insecticide for long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) was tested in this proof-of-concept study in a laboratory and semi-field environment. Laboratory-reared, insecticide-susceptible Kisumu Anopheles gambiae were exposed to IVM on impregnated netting materials and sprayed plastered- and mud walls using cone bioassays. The results showed a direct mosquitocidal effect of IVM on this mosquito strain as all mosquitoes died by 24 h after exposure to IVM. The effect was slower on the IVM-sprayed walls compared to the treated nettings. Further work to evaluate possibility of IVM as a new insecticide formulation in LLINs and IRS will be required.
(© 2024. The Author(s).)
Databáze: MEDLINE
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