Reference Ranges for Arterial Oxygen Saturation, Heart Rate, and Cerebral Oxygen Saturation during Immediate Postnatal Transition in Neonates Born Extremely or Very Preterm.

Autor: Wolfsberger CH; Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Schwaberger B; Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Urlesberger B; Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria., Avian A; Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria., Goeral K; Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria., Hammerl M; Department of Pediatrics II, Neonatology, Medical University of Innsbruck, Innsbruck, Austria., Perme T; NICU, Division of Gynaecology and Obstetrics, Department for Perinatology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Dempsey EM; INFANT Research Centre, University College Cork, Cork University Maternity Hospital, Cork, Ireland., Springer L; Department of Neonatology, University Children's Hospital of Tübingen, Tübingen, Germany., Lista G; Neonatologia e Terapia Intensiva Neonatale (TIN) Ospedale dei Bambini 'V Buzzi,' Milano, Italy., Szczapa T; II Department of Neonatology, Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit, Poznan University of Medical Sciences, Poznan, Poland., Fuchs H; Division of Neonatology and Pediatric Intensive Care Medicine, Center for Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Karpinski L; II Department of Neonatology, Neonatal Biophysical Monitoring and Cardiopulmonary Therapies Research Unit, Poznan University of Medical Sciences, Poznan, Poland., Bua J; Neonatal Intensive Care Unit, Institute for Maternal and Child Health, Trieste, Italy., Law B; Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada., Buchmayer J; Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria., Kiechl-Kohlendorfer U; Department of Pediatrics II, Neonatology, Medical University of Innsbruck, Innsbruck, Austria., Kornhauser-Cerar L; NICU, Division of Gynaecology and Obstetrics, Department for Perinatology, University Medical Centre Ljubljana, Ljubljana, Slovenia., Schwarz CE; INFANT Research Centre, University College Cork, Cork University Maternity Hospital, Cork, Ireland., Gründler K; Department of Neonatology, University Children's Hospital of Tübingen, Tübingen, Germany., Stucchi I; Neonatologia e Terapia Intensiva Neonatale (TIN) Ospedale dei Bambini 'V Buzzi,' Milano, Italy., Klebermass-Schrehof K; Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria., Schmölzer GM; Centre for the Studies of Asphyxia and Resuscitation, Neonatal Research Unit, Royal Alexandra Hospital, Edmonton, Alberta, Canada; Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada., Pichler G; Division of Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Research Unit for Neonatal Micro- and Macrocirculation, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria. Electronic address: gerhard.pichler@medunigraz.at.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2024 Oct; Vol. 273, pp. 114132. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.jpeds.2024.114132
Abstrakt: Objective: To define percentile charts for arterial oxygen saturation (SpO 2 ), heart rate (HR), and cerebral oxygen saturation (crSO 2 ) during the first 15 minutes after birth in neonates born very or extremely preterm and with favorable outcome.
Study Design: We conducted a secondary-outcome analysis of neonates born preterm included in the Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth III (COSGOD III) trial with visible cerebral oximetry measurements and with favorable outcome, defined as survival without cerebral injuries until term age. We excluded infants with inflammatory morbidities within the first week after birth. SpO 2 was obtained by pulse oximetry, and electrocardiogram or pulse oximetry were used for measurement of HR. crSO 2 was assessed with near-infrared spectroscopy. Measurements were performed during the first 15 minutes after birth. Percentile charts (10th to 90th centile) were defined for each minute.
Results: A total of 207 neonates born preterm with a gestational age of 29.7 (23.9-31.9) weeks and a birth weight of 1200 (378-2320) g were eligible for analyses. The 10th percentile of SpO 2 at minute 2, 5, 10, and 15 was 32%, 52%, 83%, and 85%, respectively. The 10th percentile of HR at minute 2, 5, 10, and 15 was 70, 109, 126, and 134 beats/min, respectively. The 10th percentile of crSO 2 at minute 2, 5, 20, and 15 was 15%, 27%, 59%, and 63%, respectively.
Conclusions: This study provides new centile charts for SpO 2 , HR, and crSO 2 for neonates born extremely or very preterm with favorable outcome. Implementing these centiles in guiding interventions during the stabilization process after birth might help to more accurately target oxygenation during postnatal transition period.
Competing Interests: Declaration of Competing Interest The COSGOD III trial received support from the Austrian Science Fund and the Health Research Board (HRB) Clinical Research Facility at the University of Cork for the submitted work and from the Stollery Children’s Hospital Foundation facilitated by the Women and Children’s Health Research Institute; no financial relationships with any organizations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. The COSGOD III trial was funded by the Austrian Science Fund (Fonds zur Förderung der wissenschaftlichen Forschung [FWF] Austria) through an unconditional and unrestricted grant (KLI 586-B31). Health Research Board (HRB) Clinical Research Facility at University College Cork supported the study at the Infant Centre, University College Cork, Cork University Maternity Hospital, Cork, Ireland. G.S. was a recipient of the Heart and Stroke Foundation/University of Alberta Professorship of Neonatal Resuscitation, a National New Investigator of the Heart and Stroke Foundation Canada, and an Alberta New Investigator of the Heart and Stroke Foundation Alberta. This research was facilitated by the Women and Children’s Health Research Institute through the support of the Stollery Children’s Hospital Foundation. No funding was received for the analysis of the data presented in the submitted manuscript, and funders had no influence on analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. The authors have no conflicts of interest relevant to this article.
(Crown Copyright © 2024. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE