Transdiagnostic failure to adapt interoceptive precision estimates across affective, substance use, and eating disorders: A replication and extension of previous results.

Autor: Lavalley CA; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA., Hakimi N; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA., Taylor S; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA., Kuplicki R; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA., Forthman KL; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA., Stewart JL; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA; Oxley College of Health & Natural Sciences, The University of Tulsa, 800 S Tucker Dr, Tulsa, OK 74104, USA., Paulus MP; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA; Oxley College of Health & Natural Sciences, The University of Tulsa, 800 S Tucker Dr, Tulsa, OK 74104, USA., Khalsa SS; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA; Oxley College of Health & Natural Sciences, The University of Tulsa, 800 S Tucker Dr, Tulsa, OK 74104, USA., Smith R; Laureate Institute for Brain Research, 6655 S Yale Ave, Tulsa, OK 74136, USA; Oxley College of Health & Natural Sciences, The University of Tulsa, 800 S Tucker Dr, Tulsa, OK 74104, USA. Electronic address: rsmith@laureateinstitute.org.
Jazyk: angličtina
Zdroj: Biological psychology [Biol Psychol] 2024 Sep; Vol. 191, pp. 108825. Date of Electronic Publication: 2024 May 31.
DOI: 10.1016/j.biopsycho.2024.108825
Abstrakt: Recent Bayesian theories of interoception suggest that perception of bodily states rests upon a precision-weighted integration of afferent signals and prior beliefs. In a previous study, we fit a computational model of perception to behavior on a heartbeat tapping task to test whether aberrant precision-weighting could explain misestimation of cardiac states in psychopathology. We found that, during an interoceptive perturbation designed to amplify afferent signal precision (inspiratory breath-holding), healthy individuals increased the precision-weighting assigned to ascending cardiac signals (relative to resting conditions), while individuals with anxiety, depression, substance use disorders, and/or eating disorders did not. In this pre-registered study, we aimed to replicate and extend our prior findings in a new transdiagnostic patient sample (N = 285) similar to the one in the original study. As expected, patients in this new sample were also unable to adjust beliefs about the precision of cardiac signals - preventing the ability to accurately perceive changes in their cardiac state. Follow-up analyses combining samples from the previous and current study (N = 719) also afforded power to identify group differences between narrower diagnostic categories, and to examine predictive accuracy when logistic regression models were trained on one sample and tested on the other. With this confirmatory evidence in place, future studies should examine the utility of interoceptive precision measures in predicting treatment outcomes and test whether these computational mechanisms might represent novel therapeutic targets.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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