Disposable electrochemical sensor: Highly sensitive determination of nitrofurazone antibiotic in environmental samples and pharmaceutical formulations.

Autor: Silva FWL; Departamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Bernardino CAR; Departamento de Engenharia Civil, COPPE, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Ferreira JHA; LabNaHm: Multifunctional Hybrid Nanomaterials Laboratory. Engineering School, Mackenzie Presbyterian University, 01302-907, São Paulo, SP, Brazil., Mahler CF; Departamento de Engenharia Civil, COPPE, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Santelli RE; Departamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; National Institute of Science & Technology of Bioanalytics (INCTBio), Campinas, Brazil., Canevari TC; LabNaHm: Multifunctional Hybrid Nanomaterials Laboratory. Engineering School, Mackenzie Presbyterian University, 01302-907, São Paulo, SP, Brazil. Electronic address: tccanevari@gmail.com., Cincotto FH; Departamento de Química Analítica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; National Institute of Science & Technology of Bioanalytics (INCTBio), Campinas, Brazil. Electronic address: fernandocincotto@iq.ufrj.br.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2024 Aug; Vol. 361, pp. 142481. Date of Electronic Publication: 2024 May 30.
DOI: 10.1016/j.chemosphere.2024.142481
Abstrakt: The study presents the successful development of a new electrochemical sensor with low cost and disposability for application in nitrofurazone detection in environmental and pharmaceutical samples. The sensors were fabricated using materials obtained from local storage and conductive carbon ink. The modification of the screen-printed electrodes with the hybrid nanomaterial based on silver nanoparticles, carbon quantum dots, and carbon nanotubes showed synergistic contributions in the nitrofurazone electrooxidation, as observed in the wide linear range (0.008 at 15.051 μM), with a sensitivity of 0.650 μA/μM. The limit of detection obtained was 4.6 nM. Differential pulse voltammetry, cyclic voltammetry, X-ray photoelectron spectroscopy, X-ray diffraction analysis, and high-resolution transmission electron microscopy were used to evaluate the electrochemical and structural characteristics. Studies of possible interferences were considered with nitrofurazone in the presence of the ions and organic molecules. The results were satisfactory, with a variation of 93.3% ± 4.39% at 100% ± 2.40%. The low volume used in the analyses (50 μL), disposability, high sensibility, selectivity, and low limit of detection are advantages that make the proposed sensor an electrochemical tool of high viability for the NFZ detection in environmental matrices and pharmaceutical formulations.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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