Urinary haloacetic acid concentrations in relation to sex and thyroid hormones among reproductive-aged men.

Autor: Chen YJ; Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Messerlian C; Departments of Environmental Health and of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States., Lu Q; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Mustieles V; Instituto de Investigación Biosanitaria Ibs GRANADA, 18012, Granada, Spain; Center for Biomedical Research (CIBM), University of Granada, 18010, Granada, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029, Madrid, Spain., Zhang Y; Departments of Environmental Health and of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States., Sun Y; Departments of Environmental Health and of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, United States; Department of Otolaryngology-Head and Neck Surgery & Center of Sleep Medicine, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital, Shanghai 200233, China., Wang L; Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, United States., Lu WQ; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China., Liu C; Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: chongliu31@shsmu.edu.cn., Wang YX; Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yixin_wang@shsmu.edu.cn.
Jazyk: angličtina
Zdroj: Environment international [Environ Int] 2024 Jul; Vol. 189, pp. 108785. Date of Electronic Publication: 2024 May 28.
DOI: 10.1016/j.envint.2024.108785
Abstrakt: Sex and thyroid hormones are critical for male reproductive health. However, the associations between haloacetic acid (HAA) exposure - a known endocrine disruptor - and sex and thyroid hormones in humans remains unclear. We thus recruited 502 male participants seeking fertility evaluation from a reproductive center. We measured concentrations of sex and thyroid hormones in a single blood sample and dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA) in repeated urine samples. Multivariable linear regression models were constructed to evaluate the associations between HAA concentrations and hormone measurements. After adjusting for potential confounders and urinary creatinine concentrations, urinary concentrations of TCAA were inversely associated with serum levels of sex hormone-binding globulin (SHBG), testosterone (T), T/luteinizing hormone ratio (T/LH), and thyroid stimulating hormone (TSH) (all P for trend < 0.10). Compared with participants in the lowest quartile of TCAA concentrations, those in the highest quartile had reduced serum levels of SHGB by 14.2 % (95% CI: -26.7, -3.0 %), T by 11.1 % (95% CI: -21.7, -1.3 %), T/LH by 21.0 % (95% CI: -36.7, -7.1 %), and TSH by 19.1 % (95% CI: -39.7, -1.5 %). Additionally, we observed inverse associations between continuous measurements of urinary HAAs and serum levels of free T, bioactive T, and estradiol. Our findings suggest that male HAA exposure may be associated with disrupted sex and thyroid function.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yixin Wang reports financial support was provided by Foundation for Innovative Research Groups of the National Natural Science Foundation of China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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