Toward Ultra-High-Quality-Factor Wireless Masing Magnetic Resonance Sensing.

Autor: Adelabu I; Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202, United States., Nantogma S; Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202, United States., Fleischer S; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Karlsruhe, Germany., Abdulmojeed M; Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695-8204, United States., de Maissin H; Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine, University of Freiburg, Killianstr. 5a, Freiburg, 79106, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany., Schmidt AB; Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202, United States.; Division of Medical Physics, Department of Radiology, Medical Center, Faculty of Medicine, University of Freiburg, Killianstr. 5a, Freiburg, 79106, Germany.; German Cancer Consortium (DKTK), Partner site Freiburg and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany., Lehmkuhl S; Institute of Microstructure Technology, Karlsruhe Institute of Technology, 76344, Eggenstein-Leopoldshafen, Karlsruhe, Germany., Rosen MS; Massachusetts General Hospital, A. A. Martinos Center for Biomedical Imaging, Boston, Massachusetts, 02129, United States.; Department of Physics, Harvard University, Cambridge, Massachusetts, 02138, United States., Appelt S; Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, 52056, Aachen, Germany.; Central Institute for Engineering, Electronics and Analytics-Electronic Systems (ZEA-2), Forschungszentrum Jülich GmbH, D-52425, Jülich, Germany., Theis T; Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27695-8204, United States., Qian C; Department of Radiology, Michigan State University, East Lansing, Michigan, 48824, United States., Chekmenev EY; Department of Chemistry, Integrative Biosciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, Michigan, 48202, United States.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Sep 09; Vol. 63 (37), pp. e202406551. Date of Electronic Publication: 2024 Jul 12.
DOI: 10.1002/anie.202406551
Abstrakt: It has recently been shown that a bolus of hyperpolarized nuclear spins can yield stimulated emission signals similar in nature to maser signals, potentially enabling new ways of sensing hyperpolarized contrast media, including most notably [1- 13 C]pyruvate that is under evaluation in over 50 clinical trials for metabolic imaging of cancer. The stimulated NMR signal emissions lasting for minutes do not require radio-frequency excitation, offering unprecedented advantages compared to conventional MR sensing. However, creating nuclear spin maser emission is challenging in practice due to stringent fundamental requirements, making practical in vivo applications hardly possible using conventional passive MR detectors. Here, we demonstrate the utility of a wireless NMR maser detector, the quality factor of which was enhanced 22-fold (to 1,670) via parametric pumping. This active-feedback technique breaks the intrinsic fundamental limit of NMR detector circuit quality factor. We show the use of parametric pumping to reduce the threshold requirement for inducing nuclear spin masing at 300 MHz resonance frequency in a preclinical MRI scanner. Indeed, stimulated emission from hyperpolarized protons was obtained under highly unfavorable conditions of low magnetic field homogeneity (T 2 * of 3 ms). Greater gains of the quality factor of the MR detector (up to 1 million) were also demonstrated.
(© 2024 Wiley-VCH GmbH.)
Databáze: MEDLINE
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