Transgenerational effects of early life stress on the fecal microbiota in mice.

Autor: Otaru N; Nutrition Research Unit, University Children's Hospital Zürich, Zürich, Switzerland.; Department of Health Sciences and Technology, Laboratory of Food Biotechnology, ETH Zürich, Zürich, Switzerland., Kourouma L; Department of Health Science and Technology of the ETH Zurich, Laboratory of Neuroepigenetics, Brain Research Institute, Medical Faculty of the University of Zurich, and Institute for Neuroscience, Zurich, Switzerland.; Center for Neuroscience Zürich, ETH and University Zürich, Zurich, Switzerland., Pugin B; Department of Health Sciences and Technology, Laboratory of Food Biotechnology, ETH Zürich, Zürich, Switzerland., Constancias F; Department of Health Sciences and Technology, Laboratory of Food Biotechnology, ETH Zürich, Zürich, Switzerland., Braegger C; Nutrition Research Unit, University Children's Hospital Zürich, Zürich, Switzerland., Mansuy IM; Department of Health Science and Technology of the ETH Zurich, Laboratory of Neuroepigenetics, Brain Research Institute, Medical Faculty of the University of Zurich, and Institute for Neuroscience, Zurich, Switzerland. mansuy@hifo.uzh.ch.; Center for Neuroscience Zürich, ETH and University Zürich, Zurich, Switzerland. mansuy@hifo.uzh.ch., Lacroix C; Department of Health Sciences and Technology, Laboratory of Food Biotechnology, ETH Zürich, Zürich, Switzerland. christophe.lacroix@hest.ethz.ch.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 May 31; Vol. 7 (1), pp. 670. Date of Electronic Publication: 2024 May 31.
DOI: 10.1038/s42003-024-06279-2
Abstrakt: Stress in early life can affect the progeny and increase the risk to develop psychiatric and cardiometabolic diseases across generations. The cross-generational effects of early life stress have been modeled in mice and demonstrated to be associated with epigenetic factors in the germline. While stress is known to affect gut microbial features, whether its effects can persist across life and be passed to the progeny is not well defined. Here we show that early postnatal stress in mice shifts the fecal microbial composition (binary Jaccard index) throughout life, including abundance of eight amplicon sequencing variants (ASVs). Further effects on fecal microbial composition, structure (weighted Jaccard index), and abundance of 16 ASVs are detected in the progeny across two generations. These effects are not accompanied by changes in bacterial metabolites in any generation. These results suggest that changes in the fecal microbial community induced by early life traumatic stress can be perpetuated from exposed parent to the offspring.
(© 2024. The Author(s).)
Databáze: MEDLINE
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