Type 2 diabetes mellitus remission in sleeve gastrectomy patients: Role of enteroendocrine response and serum citrulline and I-FABP levels.

Autor: Aydin MA; Antalya Training and Research Hospital, Department of Biochemistry, Antalya, Turkey. Electronic address: maaydin750@gmail.com., Aykal G; Antalya Training and Research Hospital, Department of Biochemistry, Antalya, Turkey. Electronic address: guzinaykal@yahoo.com., Gunduz UR; Antalya Training and Research Hospital, Department of General Surgery, Antalya, Turkey. Electronic address: utgl@yahoo.com., Dincer A; Antalya Training and Research Hospital, Department of General Surgery, Antalya, Turkey. Electronic address: aydindincer1515@gmail.com., Turker A; Antalya Training and Research Hospital, Department of General Surgery, Antalya, Turkey. Electronic address: alper_turker_@hotmail.com., Turkoglu F; Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey. Electronic address: furkanturkoglu61@hotmail.com., Guler M; Istanbul Training and Research Hospital, Department of General Surgery, Istanbul, Turkey. Electronic address: mertguler23@gmail.com.
Jazyk: angličtina
Zdroj: American journal of surgery [Am J Surg] 2024 Oct; Vol. 236, pp. 115782. Date of Electronic Publication: 2024 May 28.
DOI: 10.1016/j.amjsurg.2024.115782
Abstrakt: Introduction: This prospective cohort study examines the relationship between post-sleeve gastrectomy (SG) weight loss and serum citrulline, I-FABP levels, and the I-FABP/citrulline ratio in obese patients, alongside the correlation with type 2 diabetes mellitus (T2DM) remission.
Methods: 88 participants were enrolled, including 48 undergoing SG and 21 with T2DM. 40 healthy individuals served as controls. Preoperative and 1-year postoperative assessments included citrulline, I-FABP, glucose, insulin, HbA1c, and C peptide levels.
Results: Significant weight loss and T2DM remission (11/21) were observed post-SG. Preoperatively, patients had low citrulline and high I-FABP levels, which normalized postoperatively. A positive correlation was found between the I-FABP/citrulline ratio and weight, BMI, glucose, insulin, and C peptide levels.
Conclusion: SG not only induces enterocyte dysfunction and mass recovery but also may facilitate T2DM remission and alleviate obesity-related effects on the enteroendocrine system. These findings highlight the potential beneficial effects of SG on enteroendocrine function in obese patients.
Competing Interests: Declaration of competing interest All of the authors reported no biomedical financial interests or potential conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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