Association of CD38+ Immunophenotyping Biomarker With a Better Prognosis in Elderly Acute Myeloid Leukemia Patients.

Autor:	DE Pinho Pessoa FMC; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Oliveira DS; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil.; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Nogueira BMD; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., DE Albuquerque KMC; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Silva FAC; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Gurgel LA; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Ribeiro RM; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Medeiros JC; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Maciel ADR; Department of Hematology, Fortaleza General Hospital (HGF), Fortaleza, CE, Brazil., Barreto IV; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Machado AK; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Machado CB; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., DE Moraes Filho MO; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., DE Moraes MEA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil., Khayat AS; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém, PA, Brazil., Moreira-Nunes CA; Department of Medicine, Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Federal University of Ceará, Fortaleza, CE, Brazil; carolfam@gmail.com.; Department of Biological Sciences, Oncology Research Center, Federal University of Pará, Belém, PA, Brazil.; Clementino Fraga Group, Central Unity, Molecular Biology Laboratory, Fortaleza, CE, Brazil.
Jazyk:	angličtina
Zdroj:	Anticancer research [Anticancer Res] 2024 Jun; Vol. 44 (6), pp. 2747-2753.
DOI:	10.21873/anticanres.17083
Abstrakt:	Background/aim: The relevance of cytogenetic markers as prognostic risk factors has been demonstrated in a vast number of studies, with many prognostication tools utilizing these factors to determine treatment approaches. Patients aged above 60 years represent an important subgroup of acute myeloid leukemia (AML) patients, especially because they usually exhibit a poorer cytogenetic landscape and are less suitable for intensive treatments. The importance of evaluating prognostic parameters in AML, especially in low-income countries, prompted an investigation into CD38 expression and its effects. Patients and Methods: Medical records of AML patients aged above 60 years from three hospitals in Brazil's northwest region were analyzed. A total of 67 patients were evaluated in terms of overall survival and factors predicting worse outcomes. The risk stratification was performed based on the European LeukemiaNet 2022 guidelines. The analysis of immunophenotyping markers was conducted using multi-parametric flow cytometry. Results: The overall survival of CD38-positive AML patients was higher than that of patients with CD38-negative AML, with survival rates of 15.6 months versus 4 months, respectively (p-value=0.026). The impact of CD38 positivity was relevant also in multivariable Cox proportional hazards regression, demonstrating a positive effect on overall survival, with a hazard ratio of 0.33 (95%CI=0.13-0.79; p-value=0.014). Conclusion: Expression of CD38 in patients with AML was associated with better overall survival and serves as a relevant predictor of improved outcome in patients aged above 60 years. (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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