Interspecies transmission of antimicrobial-resistant bacteria between wild birds and mammals in urban environment.

Autor: Łopucki R; John Paul II Catholic University of Lublin, Institute of Biological Sciences, Department of Biomedicine and Environmental Research, Konstantynów 1J, Lublin 20-708, Poland., Stępień-Pyśniak D; University of Life Sciences in Lublin, Faculty of Veterinary Medicine, Department of Veterinary Prevention and Avian Diseases, Głęboka 30, Lublin 20-612, Poland. Electronic address: dagmara.stepien@up.lublin.pl., Christensen H; University of Copenhagen, Department of Veterinary and Animal Sciences, Stigbøjlen 4, Frederiksberg C, Denmark., Kubiński K; John Paul II Catholic University of Lublin, Institute of Biological Sciences, Department of Molecular Biology, Konstantynów 1J, Lublin 20-708, Poland., Lenarczyk E; John Paul II Catholic University of Lublin, Institute of Biological Sciences, Department of Biomedicine and Environmental Research, Konstantynów 1J, Lublin 20-708, Poland., Martinez-de-Tejada G; University of Navarra, Department of Microbiology and Parasitology, IdiSNA (Navarra Institute for Health Research), Irunlarrea 1, Pamplona E-31008, Spain., Kitowski I; University College of Applied Sciences in Chełm, Pocztowa 54, Chełm 22-100, Poland., Masłyk M; John Paul II Catholic University of Lublin, Institute of Biological Sciences, Department of Molecular Biology, Konstantynów 1J, Lublin 20-708, Poland.
Jazyk: angličtina
Zdroj: Veterinary microbiology [Vet Microbiol] 2024 Jul; Vol. 294, pp. 110130. Date of Electronic Publication: 2024 May 29.
DOI: 10.1016/j.vetmic.2024.110130
Abstrakt: The transmission of antibiotic-resistant bacteria among wild animal species may hold significant epidemiological implications. However, this issue is seldom explored due to the perceived complexity of these systems, which discourages experimental investigation. To address this knowledge gap, we chose a configuration of birds and mammals coexisting in an urban green area as a research model: the rook Corvus frugilegus and the striped field mouse Apodemus agrarius. The indirect transmission of antimicrobial-resistant bacteria between these species is possible because rodents inhabiting rook colonies frequently come into contact with the birds' faeces and pellets. The study was conducted in two cities in eastern Poland (Central Europe) - Lublin and Chełm. Among 71 Escherichia (E.) coli isolates studied, 19.7% showed resistance to from one to six of the antibiotics tested, with much higher prevalence of antibiotic-resistant bacteria in the birds (32%) than in the rodents (7%). Whole genome sequencing was performed on 10 selected E. coli isolates representing similar resistance phenotypes. The following antimicrobial resistance genes were detected: bla TEM-1b , tet(A), tet(B), aph(6)-Id, aph(3'')-Ib, aadA1, aadA2, catA1, floR, cmlA, sul2, sul3, dfrA14, and dfrA2. Birds from the same city and also from both neighbouring cities shared E. coli bacteria with the same sequence types, whereas isolates detected in birds were not found to have been transferred to the mammalian population, despite close contact. This demonstrates that even intensive exposure to sources of these pathogens does not necessarily lead to effective transmission of antibiotic-resistant E. coli strains between birds and mammals. Further efforts should be dedicated to investigating actual transmission of antimicrobial-resistant bacteria in various ecological systems, including those that are crucial for public health, such as urban environments. This will facilitate the development of more accurate models for epidemiological threats and the formulation of well-balanced decisions regarding the coexistence of humans and urban wildlife.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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