Modeling the effects of treatment resistance and anticholinergic burden on cognitive function domains in patients with schizophrenia.

Autor: Chan SKW; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR. Electronic address: kwsherry@hku.hk., Pang TSW; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR., Tsui HKH; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR., Suen YN; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR., Yan WC; Department of Psychiatry, Kowloon Hospital, Hong Kong SAR., Tsui CF; Department of Psychiatry, Kowloon Hospital, Hong Kong SAR., Poon LT; Department of Psychiatry, United Christian Hospital. Hong Kong SAR., Chan CWH; Department of Psychiatry, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR., Lo A; Department of Psychiatry, Kwai Chung Hospital, Hong Kong SAR., Cheung KM; Castle Peak Hospital, Hong Kong SAR., Hui CLM; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR., Chang WC; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR; The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong SAR., Lee EHM; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR., Chen EYH; Department of Psychiatry, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR., Honer WG; Department of Psychiatry, The University of British Columbia, Canada.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2024 Jul; Vol. 337, pp. 115985. Date of Electronic Publication: 2024 May 27.
DOI: 10.1016/j.psychres.2024.115985
Abstrakt: The contribution of anticholinergic burden to cognitive function in patients with treatment resistant schizophrenia (TRS) is uncertain. This case-control study aims to comprehensively examine the association between treatment resistance and cognitive functions and the contribution of anticholinergic burden in patients with schizophrenia. Anticholinergic burden of all patients was calculated using the Anticholinergic Cognitive Burden scale. Exploratory Factor Analysis of 11 cognitive assessments identified four cognitive domains: verbal memory, attention and general cognitive functions, visual memory and processing speed, and executive function. Two structural equation models (SEM) examined the relationship of TRS and these cognitive functions with, and without considering anticholinergic burden. A total of 288 participants were included (TRS N=111, non-TRS N=177). Patients with TRS performed poorer than the non-TRS group only in the executive function domain. Anticholinergic burden contributed significantly to the attention and general cognitive functions, visual memory and processing speed, and executive function. The impact of TRS on executive function was no longer significant after adding anticholinergic burden to the SEM. Results suggested that anticholinergic burden contributes to a wide range of cognitive function impairment in patients with schizophrenia and is likely to be part of the apparent differences of cognitive function between TRS and non-TRS.
Competing Interests: Declaration of competing interest No relevant conflicts of interest were reported by any of the authors.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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