Y-chromosome Degeneration due to Speciation and Founder Effect.

Autor: Zhang N; Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China., Zhang Y; Science college, Liaoning Technical University, Fuxin, China. yong.j.zhang@gmail.com.
Jazyk: angličtina
Zdroj: Acta biotheoretica [Acta Biotheor] 2024 May 31; Vol. 72 (2), pp. 6. Date of Electronic Publication: 2024 May 31.
DOI: 10.1007/s10441-024-09482-0
Abstrakt: The Y chromosome in the XY sex-determination system is often shorter than its X counterpart, a condition attributed to degeneration after Y recombination ceases. Contrary to the traditional view of continuous, gradual degeneration, our study reveals stabilization within large mating populations. In these populations, we demonstrate that both mutant and active alleles on the Y chromosome can reach equilibrium through a mutation-selection balance. However, the emergence of a new species, particularly through the founder effect, can disrupt this equilibrium. Specifically, if the male founders of a new species carry only a mutant allele for a particular Y-linked gene, this allele becomes fixed, leading to the loss of the corresponding active gene on the Y chromosome. Our findings suggest that the rate of Y-chromosome degeneration may be linked to the frequency of speciation events associated with single-male founder events.
(© 2024. Prof. Dr. Jan van der Hoeven stichting voor theoretische biologie.)
Databáze: MEDLINE
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