Neurobiological foundations and clinical relevance of effort-based decision-making.

Autor: Brassard SL; Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.; Peter Boris Center for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada., Liu H; Peter Boris Center for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada., Dosanjh J; Peter Boris Center for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada., MacKillop J; Peter Boris Center for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.; Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada.; Michael G. DeGroote Centre for Medicinal Cannabis Research, Hamilton, ON, Canada.; Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada., Balodis I; Peter Boris Center for Addictions Research, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. balodisi@mcmaster.ca.; Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, ON, Canada. balodisi@mcmaster.ca.; Michael G. DeGroote Centre for Medicinal Cannabis Research, Hamilton, ON, Canada. balodisi@mcmaster.ca.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 May 31. Date of Electronic Publication: 2024 May 31.
DOI: 10.1007/s11682-024-00890-x
Abstrakt: Applying effort-based decision-making tasks provides insights into specific variables influencing choice behaviors. The current review summarizes the structural and functional neuroanatomy of effort-based decision-making. Across 39 examined studies, the review highlights the ventromedial prefrontal cortex in forming reward-based predictions, the ventral striatum encoding expected subjective values driven by reward size, the dorsal anterior cingulate cortex for monitoring choices to maximize rewards, and specific motor areas preparing for effort expenditure. Neuromodulation techniques, along with shifting environmental and internal states, are promising novel treatment interventions for altering neural alterations underlying decision-making. Our review further articulates the translational promise of this construct into the development, maintenance and treatment of psychiatric conditions, particularly those characterized by reward-, effort- and valuation-related deficits.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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