Impact of Variable Sampling on Estimates of HIV-1 Reservoir Formation Dates.

Autor:	Kankaka EN; Rakai Health Sciences Program, Kalisizo, Uganda., Poon AFY; Department of Pathology and Laboratory Medicine, Western University, London, Ontario, Canada., Quinn TC; Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA.; Division of Intramural Research, Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, Baltimore, MD, USA., Chang LW; Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA., Prodger JL; Department of Microbiology and Immunology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada., Redd AD; Division of Infectious Diseases, Johns Hopkins University, Baltimore, MD, USA.; Division of Intramural Research, Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, Baltimore, MD, USA.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Oct 16; Vol. 230 (4), pp. 928-932.
DOI:	10.1093/infdis/jiae294
Abstrakt:	Timing of human immunodeficiency virus-1 (HIV-1) reservoir formation is important for informing HIV cure efforts. It is unclear how much of the variability seen in dating reservoir formation is due to sampling and gene-specific differences. We used a Bayesian extension of root to tip regression (bayroot) to reestimate formation date distributions in participants from Swedish and South African cohorts, and assessed the impact of variable timing, frequency, and depth of sampling on these estimates. Significant shifts in formation date distributions were only observed with use of faster-evolving genes, while timing, frequency, and depth of sampling had minor or no significant effect on estimates. Competing Interests: Potential conflicts of interest . All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (Published by Oxford University Press on behalf of Infectious Diseases Society of America 2024.)
Databáze:	MEDLINE
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