Association between renal α-klotho and renal pathology among patients with chronic kidney disease.

Autor: Guo Y; Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang, China., Wan F; Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang, China., Shi YP; Linping Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang, China., Zhang HM; Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China., Yang RC; Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.; Key Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang, China.
Jazyk: angličtina
Zdroj: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy [Ther Apher Dial] 2024 Oct; Vol. 28 (5), pp. 769-774. Date of Electronic Publication: 2024 May 31.
DOI: 10.1111/1744-9987.14165
Abstrakt: Introduction: This study was designed to investigate whether renal α-klotho levels are associated with renal pathology. This is the first report on patients with chronic kidney disease (CKD).
Methods: We conducted a retrospective observational study. A total of 65 CKD patients were enrolled. Serum and renal biopsy samples were collected. Estimated glomerular filtration rate (eGFR) was examined by biochemical test. And α-klotho expressions were assessed by RT-PCR and immunohistochemistry. In addition, detailed microscopic findings were reviewed.
Results: Renal α-klotho levels are associated positively with eGFR, and negatively with renal pathology, including interstitial fibrosis, inflammatory cell infiltration, and tubular atrophy.
Conclusions: The renal α-klotho is related to renal pathology.
(© 2024 International Society for Apheresis and Japanese Society for Apheresis.)
Databáze: MEDLINE
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