The Potential of Nano Pharmaceuticals to Change the Paradigm of Brain Tumor Therapy: A State-of-the-Art Review.

Autor:	Zahid A; Cardiff University School of Medicine, Cardiff University, Cardiff, Wales, UK.; Pear Research, Dehradun, India., Hammoud Z; Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon.; Pear Research, Dehradun, India., Farhat S; Lebanese University, Faculty of Medical Sciences, Beirut, Lebanon.; Pear Research, Dehradun, India., Kaiwan O; Pear Research, Dehradun, India.; Northeast Ohio Medical University, Ohio, USA., Al-Inaya Y; Uzhhorod National University, Uzhhorod, Ukraine.; Pear Research, Dehradun, India., Cortiana V; University of Bologna, Bologna, Italy.; Pear Research, Dehradun, India., Pahwa B; UCMS and GTB Hospital, Delhi.; Pear Research, Dehradun, India., Chopra H; Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, 602105, India., Parmar M; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Tampa Bay Regional Campus, Clearwater, Florida, USA., Kamal MA; Joint Laboratory of Artificial Intelligence in Healthcare, West China School of Nursing and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China.; King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.; Enzymoics, 7 Peterlee place, Hebersham, NSW 2770; Novel Global Community Educational Foundation, Australia.; Government Doon Medical College, Dehradun, Uttarakhand, India., Sethi Y; Pear Research, Dehradun, India.
Jazyk:	angličtina
Zdroj:	Current cancer drug targets [Curr Cancer Drug Targets] 2024 May 30. Date of Electronic Publication: 2024 May 30.
DOI:	10.2174/0115680096286740240507092553
Abstrakt:	Central nervous system tumors are abnormal proliferations of neuronal cells within the brain and spinal cord. They can be primary or secondary and place a heavy financial, psychological, and physical burden on individuals. The highly selective blood-brain barrier, which only permits specific molecules to flow into the brain parenchyma, inhibits the efficacy of pharmacological medicines. Treatment options include surgery, chemoradiotherapy, and targeted therapy. Despite advances in therapy over the past few decades, the overall morbidity and mortality rates are still high, emphasizing the need for improved therapeutic choices to improve survival and quality of life further. Nano pharmaceuticals have demonstrated encouraging outcomes in in vivo trials using microscopic particles to enhance bioavailability and selectivity. The most successful clinical results to date have been achieved by liposomes, extracellular vesicles, and biomimetic nanoparticles; nevertheless, clinical trials are required to confirm their safety, efficacy, affordability, longterm impact, and success in patients from various demographics. Nano pharmaceuticals have the potential to change the paradigm of therapy for brain tumors, allowing better outcomes as primary and adjunctive therapy. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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