Dengue virus transmission risk in blood donation: Evidence from Thailand.

Autor: Limothai U; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand., Tachaboon S; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand., Dinhuzen J; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand., Singh J; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand.; School of Global Health, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Thailand Public Health Research Fellowship, Health Education England, London, UK., Leewongworasingh A; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand., Watanaboonyongcharoen P; Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University and Transfusion Medicine Unit, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Fernandez S; Department of Virology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand., Hunsawong T; Department of Virology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand., Farmer AR; Department of Virology, Armed Forces Research Institute of Medical Sciences (AFRIMS), Bangkok, Thailand., Tantawichien T; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand.; Division of Infectious Diseases, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Thisyakorn U; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand., Srisawat N; Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Center of Excellence in Critical Care Nephrology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Tropical Medicine Cluster, Chulalongkorn University, Bangkok, Thailand.; Division of Nephrology, Department of Medicine, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Department of Critical Care Medicine, Center for Critical Care Nephrology, The CRISMA Center, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Academy of Science, Royal Society of Thailand, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2024 Jun; Vol. 96 (6), pp. e29689.
DOI: 10.1002/jmv.29689
Abstrakt: Individuals infected with dengue virus (DENV) often show no symptoms, which raises the risk of DENV transfusion transmission (TT-DENV) in areas where the virus is prevalent. This study aimed to determine the evidence of DENV infection in blood donors from different geographic regions of Thailand. A cross-sectional study was conducted on blood donor samples collected from the Thai Red Cross National Blood Center and four regional blood centers between March and September 2020. Screening for DENV nonstructural protein 1 (NS1), anti-DENV immunoglobulin G (IgG), and IgM antibodies was performed on residual blood from 1053 donors using enzyme-linked immunosorbent assay kits. Positive NS1 and IgM samples indicating acute infection were verified using four different techniques, including quantitative real-time (q) RT-PCR, nested PCR, virus isolation in C6/36 cells, and mosquito amplification. DENV IgG seropositivity was identified in 89% (938/1053) of blood donors. Additionally, 0.4% (4/1053) and 2.1% (22/1053) of Thai blood donors tested positive for NS1 and IgM, respectively. The presence of asymptomatic dengue virus infection in healthy blood donors suggests a potential risk of transmission through blood transfusion, posing a concern for blood safety.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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