| Autor: |
Robinette LM; Department of Human Sciences, The Ohio State University, Columbus, OH, USA., Johnstone JM; Center for Mental Health Innovation, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.; National University of Natural Medicine, Helfgott Research Institute, Portland, OR, USA., Srikanth P; Oregon Health & Science University, Portland, OR, USA., Bruton AM; Center for Mental Health Innovation, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA., Ralle M; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA., Ast HK; Center for Mental Health Innovation, Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA., Bradley RD; National University of Natural Medicine, Helfgott Research Institute, Portland, OR, USA.; Herbert Wertheim School of Public Health, University of California San Diego, San Diego, CA, USA., Leung B; Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, Canada., Arnold LE; Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH, USA., Hatsu IE; Department of Human Sciences, The Ohio State University, Columbus, OH, USA.; OSU Extension, The Ohio State University, Columbus, OH, USA. |
| Abstrakt: |
Essential minerals are cofactors for synthesis of neurotransmitters supporting cognition and mood. An 8-week fully-blind randomised controlled trial of multinutrients for attention-deficit/hyperactivity disorder (ADHD) demonstrated three times as many children (age 6-12) had significantly improved behaviour ('treatment responders') on multinutrients (54 %) compared with placebo (18 %). The aim of this secondary study was to evaluate changes in fasted plasma and urinary mineral concentrations following the intervention and their role as mediators and moderators of treatment response. Fourteen essential or trace minerals were measured in plasma and/or urine at baseline and week eight from eighty-six participants (forty-nine multinutrients, thirty-seven placebos). Two-sample t tests/Mann-Whitney U tests compared 8-week change between treatment and placebo groups, which were also evaluated as potential mediators. Baseline levels were evaluated as potential moderators, using logistic regression models with clinical treatment response as the outcome. After 8 weeks, plasma boron, Cr (in females only), Li, Mo, Se and vanadium and urinary iodine, Li and Se increased more with multinutrients than placebo, while plasma phosphorus decreased. These changes did not mediate treatment response. However, baseline urinary Li trended towards moderation: participants with lower baseline urinary Li were more likely to respond to multinutrients ( P = 0·058). Additionally, participants with higher baseline Fe were more likely to be treatment responders regardless of the treatment group ( P = 0·036.) These results show that multinutrient treatment response among children with ADHD is independent of their baseline plasma mineral levels, while baseline urinary Li levels show potential as a non-invasive biomarker of treatment response requiring further study. |
