In situ light-activated materials for skin wound healing and repair: A narrative review.

Autor: Yaron JR; Center for Biomaterials Innovation and Translation, The Biodesign Institute, Arizona State University Tempe Arizona USA.; School for Engineering of Matter, Transport, and Energy, Ira A. Fulton Schools of Engineering, Arizona State University Tempe Arizona USA., Gosangi M; Center for Biomaterials Innovation and Translation, The Biodesign Institute, Arizona State University Tempe Arizona USA., Pallod S; Center for Biomaterials Innovation and Translation, The Biodesign Institute, Arizona State University Tempe Arizona USA., Rege K; Center for Biomaterials Innovation and Translation, The Biodesign Institute, Arizona State University Tempe Arizona USA.; School for Engineering of Matter, Transport, and Energy, Ira A. Fulton Schools of Engineering, Arizona State University Tempe Arizona USA.; Chemical Engineering, Arizona State University Tempe Arizona USA.
Jazyk: angličtina
Zdroj: Bioengineering & translational medicine [Bioeng Transl Med] 2024 Jan 16; Vol. 9 (3), pp. e10637. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).
DOI: 10.1002/btm2.10637
Abstrakt: Dermal wounds are a major global health burden made worse by common comorbidities such as diabetes and infection. Appropriate wound closure relies on a highly coordinated series of cellular events, ultimately bridging tissue gaps and regenerating normal physiological structures. Wound dressings are an important component of wound care management, providing a barrier against external insults while preserving the active reparative processes underway within the wound bed. The development of wound dressings with biomaterial constituents has become an attractive design strategy due to the varied functions intrinsic in biological polymers, such as cell instructiveness, growth factor binding, antimicrobial properties, and tissue integration. Using photosensitive agents to generate crosslinked or photopolymerized dressings in situ provides an opportunity to develop dressings rapidly within the wound bed, facilitating robust adhesion to the wound bed for greater barrier protection and adaptation to irregular wound shapes. Despite the popularity of this fabrication approach, relatively few experimental wound dressings have undergone preclinical translation into animal models, limiting the overall integrity of assessing their potential as effective wound dressings. Here, we provide an up-to-date narrative review of reported photoinitiator- and wavelength-guided design strategies for in situ light activation of biomaterial dressings that have been evaluated in preclinical wound healing models.
Competing Interests: Jordan R. Yaron is affiliated with Vivo Bioconsulting, LLC and Endotat Biotechnologies, LLC. Kaushal Rege is affiliated with Synergyan, LLC and Endotat Biotechnologies, LLC. Other authors declare no conflict of interest.
(© 2024 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers.)
Databáze: MEDLINE
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