Assessment of histology's performance compared with PCR in the diagnosis of Helicobacter pylori infection.

Autor:	Moalla M; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Chtourou L; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Mnif B; Microbiology department, Habib Bourguiba hospital, Sfax, Tunisia., Charfi S; Pathology department, Habib Bourguiba hospital, Sfax, Tunisia., Smaoui H; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Boudabous M; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Mnif L; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Amouri A; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Gdoura H; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia., Hammami A; Microbiology department, Habib Bourguiba hospital, Sfax, Tunisia., Boudawara T; Pathology department, Habib Bourguiba hospital, Sfax, Tunisia., Tahri N; Gastroenterology department, Hedi Chaker hospital, Sfax, Tunisia.
Jazyk:	angličtina
Zdroj:	Future science OA [Future Sci OA] 2024 May 14; Vol. 10 (1), pp. FSO976. Date of Electronic Publication: 2024 May 14 (Print Publication: 2024).
DOI:	10.2144/fsoa-2023-0217
Abstrakt:	Aim: Histology is the most widely used test to detect H. pylori . PCR is less used but allows the detection of both infection and antibiotics' resistance. Methods: We conducted a monocentric cross-sectional study, collecting 97 symptomatic patients to assess the diagnostic performance of histology in the detection of H. pylori infection compared with PCR. Results: Sensitivity of histology in comparison with PCR was 81.5% and specificity was 56.3%. A history of anti- H. pylori therapy intake, as well as the density of the bacterium on the gastric sample and the presence of gastric atrophy, were significantly correlated to the PCR's result in terms of H. pylori detection. Conclusion: Thus, histology can be considered as an efficient test compared with PCR in H. pylori detection. Competing Interests: The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. (© 2024 Manel Moalla.)
Databáze:	MEDLINE
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