Systematic exploration of network pharmacology, in silico modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome.
| Autor: | Begum RF; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur-603203, Chengalpattu, Tamil Nadu, India., Mohan S; Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science & Technology, Kattankulathur-603203, Chengalpattu, Tamil Nadu, India. |
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| Jazyk: | angličtina |
| Zdroj: | Future science OA [Future Sci OA] 2024 May 15; Vol. 10 (1), pp. FSO952. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024). |
| DOI: | 10.2144/fsoa-2023-0245 |
| Abstrakt: | Aim: This study seeks to explore the possibility of using vitamin E to alleviate the symptoms of polycystic ovarian syndrome (PCOS). Methods: Various computational methods were employed, including network pharmacology utilizing a compound-target-pathway approach, Swiss ADME, OSIRIS ® property explorer, pkCSM, PASS online web resource and MOLINSPIRATION ® software. In addition, in silico analysis of vitamin E was performed with ten receptors. Results & discussion: Our findings highlight the diverse potential of vitamin E in alleviating PCOS. The observed influence on hormones is in line with existing PCOS theories regarding cyst development, further enhancing the therapeutic promise of vitamin E. Conclusion: In conclusion, our computational analysis indicates that vitamin E shows potential as a therapeutic agent for alleviating PCOS in adolescents. Competing Interests: The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. (© 2024 Dr. Rukaiah Fatma Begum.) |
| Databáze: | MEDLINE |
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