Aging atlas reveals cell-type-specific effects of pro-longevity strategies.

Autor: Gao SM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA., Qi Y; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Zhang Q; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA., Guan Y; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; Molecular and Cellular Biology Graduate Program, Baylor College of Medicine, Houston, TX, USA., Lee YT; Integrative Program of Molecular and Biochemical Science, Baylor College of Medicine, Houston, TX, USA., Ding L; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; Graduate Program in Chemical, Physical & Structural Biology, Graduate School of Biomedical Sciences, Baylor College of Medicine, Houston, TX, USA., Wang L; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Mohammed AS; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA., Li H; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA. hongjie.li@bcm.edu.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. hongjie.li@bcm.edu., Fu Y; Huffington Center on Aging, Baylor College of Medicine, Houston, TX, USA. yusifu@creighton.edu.; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, USA. yusifu@creighton.edu., Wang MC; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. mengwang@janelia.hhmi.org.
Jazyk: angličtina
Zdroj: Nature aging [Nat Aging] 2024 Jul; Vol. 4 (7), pp. 998-1013. Date of Electronic Publication: 2024 May 30.
DOI: 10.1038/s43587-024-00631-1
Abstrakt: Organismal aging involves functional declines in both somatic and reproductive tissues. Multiple strategies have been discovered to extend lifespan across species. However, how age-related molecular changes differ among various tissues and how those lifespan-extending strategies slow tissue aging in distinct manners remain unclear. Here we generated the transcriptomic Cell Atlas of Worm Aging (CAWA, http://mengwanglab.org/atlas ) of wild-type and long-lived strains. We discovered cell-specific, age-related molecular and functional signatures across all somatic and germ cell types. We developed transcriptomic aging clocks for different tissues and quantitatively determined how three different pro-longevity strategies slow tissue aging distinctively. Furthermore, through genome-wide profiling of alternative polyadenylation (APA) events in different tissues, we discovered cell-type-specific APA changes during aging and revealed how these changes are differentially affected by the pro-longevity strategies. Together, this study offers fundamental molecular insights into both somatic and reproductive aging and provides a valuable resource for in-depth understanding of the diversity of pro-longevity mechanisms.
(© 2024. The Author(s).)
Databáze: MEDLINE
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