The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis.

Autor: Stockbridge RB; Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, 48109, USA. stockbr@umich.edu., Wackett LP; Department of Biochemistry, Biophysics & Molecular Biology and Biotechnology Institute, University of Minnesota, Minneapolis, MN, 55455, USA. wacke003@umn.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 30; Vol. 15 (1), pp. 4593. Date of Electronic Publication: 2024 May 30.
DOI: 10.1038/s41467-024-49018-1
Abstrakt: Fluorinated organic chemicals, such as per- and polyfluorinated alkyl substances (PFAS) and fluorinated pesticides, are both broadly useful and unusually long-lived. To combat problems related to the accumulation of these compounds, microbial PFAS and organofluorine degradation and biosynthesis of less-fluorinated replacement chemicals are under intense study. Both efforts are undermined by the substantial toxicity of fluoride, an anion that powerfully inhibits metabolism. Microorganisms have contended with environmental mineral fluoride over evolutionary time, evolving a suite of detoxification mechanisms. In this perspective, we synthesize emerging ideas on microbial defluorination/fluorination and fluoride resistance mechanisms and identify best approaches for bioengineering new approaches for degrading and making organofluorine compounds.
(© 2024. The Author(s).)
Databáze: MEDLINE
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