Gene expression signatures in blood from a West African sepsis cohort define host response phenotypes.

Autor: Chenoweth JG; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA. jchenoweth@aceso-sepsis.org., Colantuoni C; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Striegel DA; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Genzor P; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Brandsma J; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Blair PW; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.; Department of Pathology, Uniformed Services University, Bethesda, MD, USA., Krishnan S; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Chiyka E; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Fazli M; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Mehta R; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Considine M; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Cope L; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA., Knight AC; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Elayadi A; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA., Fox A; Naval Medical Research Unit EURAFCENT Ghana detachment, Accra, Ghana., Hertzano R; Section on Omics and Translational Science of Hearing, Neurotology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA., Letizia AG; Naval Medical Research Unit EURAFCENT Ghana detachment, Accra, Ghana., Owusu-Ofori A; Laboratory Services Directorate, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana.; Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana., Boakye I; Research and Development Unit, KATH, Kumasi, Ghana., Aduboffour AA; Laboratory Services Directorate, Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana., Ansong D; Child Health Directorate, KATH, Kumasi, Ghana.; Department of Child Health, KNUST, Kumasi, Ghana., Biney E; Accident and Emergency Department, KATH, Kumasi, Ghana., Oduro G; Accident and Emergency Department, KATH, Kumasi, Ghana., Schully KL; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), Biological Defense Research Directorate, Naval Medical Research Command-Frederick, Ft. Detrick, MD, USA., Clark DV; Austere environments Consortium for Enhanced Sepsis Outcomes (ACESO), The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 May 30; Vol. 15 (1), pp. 4606. Date of Electronic Publication: 2024 May 30.
DOI: 10.1038/s41467-024-48821-0
Abstrakt: Our limited understanding of the pathophysiological mechanisms that operate during sepsis is an obstacle to rational treatment and clinical trial design. There is a critical lack of data from low- and middle-income countries where the sepsis burden is increased which inhibits generalized strategies for therapeutic intervention. Here we perform RNA sequencing of whole blood to investigate longitudinal host response to sepsis in a Ghanaian cohort. Data dimensional reduction reveals dynamic gene expression patterns that describe cell type-specific molecular phenotypes including a dysregulated myeloid compartment shared between sepsis and COVID-19. The gene expression signatures reported here define a landscape of host response to sepsis that supports interventions via targeting immunophenotypes to improve outcomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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