Molecular allergology: a clinical laboratory tool for precision diagnosis, stratification and follow-up of allergic patients.

Autor:	Giusti D; Immunology Laboratory, Biology and Pathology Department, University Hospital of Reims, Reims, France.; University of Reims Champagne Ardenne, EA7509 IRMAIC, Reims, France., Guemari A; Univ Montpellier, Desbrest Institute of Epidemiology and Public Health (IDESP), INSERM, Montpellier, France., Perotin JM; Department of Respiratory Diseases, University Hospital of Reims, Reims, France.; University of Reims Champagne Ardenne, INSERM UMR 1250, Reims, France., Fontaine JF; Department of Respiratory Diseases, University Hospital of Reims, Reims, France., Tonye Libyh M; Immunology Laboratory, Biology and Pathology Department, University Hospital of Reims, Reims, France., Gatouillat G; Immunology Laboratory, Biology and Pathology Department, University Hospital of Reims, Reims, France., Tabary T; Immunology Laboratory, Biology and Pathology Department, University Hospital of Reims, Reims, France., Pham BN; Immunology Laboratory, Biology and Pathology Department, University Hospital of Reims, Reims, France.; University of Reims Champagne Ardenne, EA7509 IRMAIC, Reims, France., Vitte J; Immunology Laboratory, Biology and Pathology Department, University Hospital of Reims, Reims, France.; University of Reims Champagne Ardenne, INSERM UMR 1250, Reims, France.
Jazyk:	angličtina
Zdroj:	Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2024 May 31; Vol. 62 (12), pp. 2339-2355. Date of Electronic Publication: 2024 May 31 (Print Publication: 2024).
DOI:	10.1515/cclm-2024-0305
Abstrakt:	Identification of the molecular culprits of allergic reactions leveraged molecular allergology applications in clinical laboratory medicine. Molecular allergology shifted the focus from complex, heterogeneous allergenic extracts, e.g. pollen, food, or insect venom, towards genetically and immunologically defined proteins available for in vitro diagnosis. Molecular allergology is a precision medicine approach for the diagnosis, stratification, therapeutic management, follow-up and prognostic evaluation of patients within a large range of allergic diseases. Exclusively available for in vitro diagnosis, molecular allergology is nonredundant with any of the current clinical tools for allergy investigation. As an example of a major application, discrimination of genuine sensitization from allergen cross-reactivity at the molecular level allows the proper targeting of the culprit allergen and thus dramatically improves patient management. This review aims at introducing clinical laboratory specialists to molecular allergology, from the biochemical and genetic bases, through immunological concepts, to daily use in the diagnosis and management of allergic diseases. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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