Systematic review and meta-analysis for the 2024 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis.

Autor:	Nakayama Y; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nagata W; Department of Pharmacology, National Defense Medical College, Tokorozawa, Japan., Takeuchi Y; Department of Rheumatology and Nephrology, Japanese Red Cross Maebashi Hospital, Maebashi, Japan., Fukui S; Department of Emergency and General Medicine, Kyorin University School of Medicine, Tokyo, Japan., Fujita Y; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Hosokawa Y; Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan., Ueno M; The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan., Ono K; Department of Joint Surgery, Research Hospital, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan., Sumitomo S; Department of Rheumatology, Kobe City Medical Center General Hospital, Kobe, Japan., Tabuchi Y; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nakanishi Y; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Saito S; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan., Ikeuchi H; Department of Preventive Services, School of Public Health, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan., Kawamori K; Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan., Sofue H; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Doi G; Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan., Minami R; Department of Orthopaedic Surgery and Rheumatology, Otokoyama Hospital, Kyoto, Japan., Hirota T; Department of Infection and Rheumatology, University of Fukui Hospital, Fukui, Japan., Minegishi K; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Maeshima K; Department of Rheumatology, Nishida Hospital, Saiki, Japan., Motoyama R; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan., Nakamura S; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan., Suzuki S; Department of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan., Nishioka N; Department of Preventive Services, School of Public Health, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto, Japan., Wada TT; Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Onishi A; Department of Advanced Medicine of Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Nishimura K; Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan., Watanabe R; Department of Clinical Immunology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan., Yanai R; Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan., Kida T; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Nishiwaki H; Division of Nephrology, Department of Internal Medicine, Showa University Fujigaoka Hospital, Yokohama, Japan., Yajima N; Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan., Kaneko Y; Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Tanaka E; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan., Kawahito Y; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan., Harigai M; Division of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Modern rheumatology [Mod Rheumatol] 2024 May 30. Date of Electronic Publication: 2024 May 30.
DOI:	10.1093/mr/roae049
Abstrakt:	Objectives: To update evidence on the efficacy and safety of disease-modifying antirheumatic drugs (DMARDs) and provide information to the taskforce for the 2024 update of the Japan College of Rheumatology (JCR) clinical practice guidelines (CPG) for the management of rheumatoid arthritis (RA). Methods: We searched various databases for randomised controlled trials on RA published until June 2022, with no language restriction. For each of the 15 clinical questions, 2 independent reviewers screened the articles, evaluated the core outcomes, and performed meta-analyses. Results: Subcutaneous injection of methotrexate (MTX) showed similar efficacy to oral MTX in MTX-naïve RA patients. Ozoralizumab combined with MTX improved drug efficacy compared to the placebo in RA patients with inadequate response (IR) to csDMARD. Rituximab with and without concomitant csDMARDs showed similar efficacy to other bDMARDs in bDMARD-IR RA patients. Combined Janus kinase inhibitors and MTX achieved similar clinical responses and equal safety during a 4-year period compared to tumour necrosis factor inhibitors in MTX-IR RA patients. Biosimilars showed efficacy equivalent to that of the original bDMARDs in csDMARD-IR and bDMARD-IR RA patients. Conclusion: This systematic review provides latest evidence for the 2024 update of the JCR CPG for RA management. (© Japan College of Rheumatology 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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