Antidepressant-related microstructural changes in the external capsule.

Autor: Kerpel A; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. arikerp@gmail.com., Davenport E; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Proskovec AL; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Xi Y; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Berry JD; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Yetkin Z; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Maldjian J; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Yu FF; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Jazyk: angličtina
Zdroj: Brain imaging and behavior [Brain Imaging Behav] 2024 Oct; Vol. 18 (5), pp. 1044-1051. Date of Electronic Publication: 2024 May 30.
DOI: 10.1007/s11682-024-00891-w
Abstrakt: Several magnetic resonance imaging (MRI) studies have reported that antidepressant medications are strongly linked to brain microstructural alterations. Notably, external capsule alterations have been reported to be a biological marker for therapeutic response. However, prior studies did not investigate whether a change in the neurite density or directional coherence of white matter (WM) fibers underlies the observed microstructural alterations. This MRI-based case-control study examined the relationship between patients' current use of antidepressant medications and advanced measurements of external capsule WM microstructure derived from multishell diffusion imaging using neurite orientation dispersion and density imaging (NODDI). The study compared a group of thirty-five participants who were taking antidepressant medications comprising selective serotonin reuptake inhibitors (SSRIs) (n = 25) and serotonin and norepinephrine reuptake inhibitors (SNRIs) with a control group of thirty-five individuals matched in terms of age, sex, race, and atherosclerotic cardiovascular risk factors. All participants were selected from the Dallas Heart Study phase 2, a multi-ethnic, population-based cohort study. A series of multiple linear regression analyses were conducted to predict microstructural characteristics of the bilateral external capsule using age, sex, and antidepressant medications as predictor variables. There was significantly reduced neurite density in the bilateral external capsules of patients taking SSRIs. Increased orientation dispersion in the external capsule was predominantly seen in patients taking SNRIs. Our findings suggest an association between specific external capsule microstructural changes and antidepressant medications, including reduced neurite density for SSRIs and increased orientation dispersion for SNRIs.
Competing Interests: Declarations. Ethics approval: The study was approved by the Institutional Review Board (IRB) of The University of Texas Southwestern Medical Center, Dallas, Texas. The study has been conducted in accordance with the Declaration of Helsinki. Consent to participate: The DHS subjects provided written informed consent. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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