| Autor: |
Aminnezhad S; Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran. aminnezhad.bio84@gmail.com., Hassan Aubais Aljelehawy Q; Department of Chemistry, College of Education, University of Alqadisiya, Iraq . qassim.hassan@qu.edu.iq., Rezaei M; Department of Biotechnology, school of science and Technology, Nottingham Trent University, Nottingham, UK. mrezaei2239@gmail.com., Mohammadi MR; Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran . mohammadi.mreza73@gmail.com., Zonobian MA; Department of Food Microbiology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran . mohammadalizonobian.official@yahoo.com., Nazari M; Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran . masume.nazarii1994@gmail.com., Fathi F; Cellular and Molecular Research Center, Kurdistan University of Medical Sciences, 6617713446 Sanandaj, Kurdistan, Iran. farfath@gmail.com., Dadpour S; Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. sabadp@gmail.com., Habibi P; Islamic Azad University, Science and Research, Tehran, Iran. pariahabibi@gmail.com., Kashanian S; Faculty of Chemistry, Razi University, Kermanshah 6714414971, Iran; Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah 6714414971, Iran. kashanians@gmail.com., Ashengroph M; Department of Biological Science, Faculty of Science, University of Kurdistan, Sanandaj, Kurdistan, Iran; Research Center for Nanotechnology, University of Kurdistan, Sanandaj, Kurdistan 66177-15175, Iran. m.ashengroph@uok.ac.ir., Mohammadzade H; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran. hadi.karaj88@yahoo.com., Azarakhsh Y; Department of Basic Science & Pathobiology, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. josef.azarakhsh@gmail.com., Kahrizi S; Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. sepehrkahrizi84@gmail.com., Alavi M; Nanobiotechnology Department, Faculty of innovative Science and Technology, Razi University, Kermanshah, Iran. mehranbio83@gmail.com., Xu Z; Department of Gastrointestinal Surgery, The Affiliated Taian City Centeral Hospital of Qingdao University,Tai'an, Shandong Province, China. 850439391@qq.com. |
| Abstrakt: |
Molecularly imprinted polymers (MIPs) are pivotal in medicine, mimicking biological receptors with enhanced specificity and affinity. Comprising templates, functional monomers, and cross-linkers, MIPs form stable three-dimensional polymer networks. Synthetic templates like glycan and aptamers improve efficiency, guiding the molecular imprinting process. Cross-linking determines MIPs' morphology and mechanical stability, with printable hydrogels offering biocompatibility and customizable properties, mimicking native extracellular matrix (ECM) microenvironments. Their versatility finds applications in tissue engineering, soft robotics, regenerative medicine, and wastewater treatment. In cancer research, MIPs excel in both detection and therapy. MIP-based detection systems exhibit superior sensitivity and selectivity for cancer biomarkers. They target nucleic acids, proteins, and exosomes, providing stability, sensitivity, and adaptability. In therapy, MIPs offer solutions to challenges like multidrug resistance, excelling in drug delivery, photodynamic therapy, photothermal therapy, and biological activity regulation. In microbiology, MIPs serve as adsorbents in solid-phase extraction (SPE), efficiently separating and enriching antibiotics during sample preparation. They contribute to bacterial identification, selectively capturing specific strains or species. MIPs aid in detecting antibiotic residues using fluorescent nanostructures and developing sensors for sulfadiazine detection in food samples. In summary, MIPs play a pivotal role in advancing medical technologies with enhanced sensitivity, selectivity, and versatility. Applications range from biomarker detection to innovative cancer therapies, making MIPs indispensable for the accurate determination and monitoring of diverse biological and environmental samples. |
