Thalamic activity-dependent specification of sensory input neurons in the developing chick entopallium.

Autor: Katayama R; Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, Tokyo, Japan.; Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.; Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Kumamoto T; Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Wada K; Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.; School of Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan., Hanashima C; Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, Tokyo, Japan.; Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan., Ohtaka-Maruyama C; Developmental Neuroscience Project, Department of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.; School of Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Jazyk: angličtina
Zdroj: The Journal of comparative neurology [J Comp Neurol] 2024 Jun; Vol. 532 (6), pp. e25627.
DOI: 10.1002/cne.25627
Abstrakt: During development, cell-intrinsic and cell-extrinsic factors play important roles in neuronal differentiation; however, the underlying mechanisms in nonmammalian species remain largely unknown. We here investigated the mechanisms responsible for the differentiation of sensory input neurons in the chick entopallium, which receives its primary visual input via the tectofugal pathway from the nucleus rotundus. The results obtained revealed that input neurons in the entopallium expressed Potassium Voltage-Gated Channel Subfamily H Member 5 (KCNH5/EAG2) mRNA from embryonic day (E) 11. On the other hand, the onset of protein expression was E20, which was 1 day before hatching. We confirm that entopallium input neurons in chicks were generated during early neurogenesis in the lateral and ventral ventricular zones. Notably, neurons derived from the lateral (LP) and ventral pallium (VP) exhibited a spatially distinct distribution along the rostro-caudal axis. We further demonstrated that the expression of EAG2 was directly regulated by input activity from thalamic axons. Collectively, the present results reveal that thalamic input activity is essential for specifying input neurons among LP- and VP-derived early-generated neurons in the developing chick entopallium.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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