| Autor: |
Wang XQ; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China., Liu B; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China., Wang ZM; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China., Zhao SN; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China., Weng XG; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China., Guo SY; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China., Sun Y; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2024 May; Vol. 49 (10), pp. 2722-2727. |
| DOI: |
10.19540/j.cnki.cjcmm.20240311.201 |
| Abstrakt: |
This study investigated the chemical and biological activity of the secondary metabolites from an endophytic fungus Fusa-rium solani MBM-5 of Datura arborea. A total of six alkenoic acid compounds, including a new compound and five known ones, were isolated from the ethyl acetate extract of F. solani MBM-5 by using the chromatographic methods(open ODS column chromatography, silica gel column chromatography, Sephadex LH-20, and semi-preparative HPLC). The structures of the compounds were identified by using their physical and chemical data, spectroscopic methods(UV, IR, NMR, and HR-ESI-MS), and Mosher's reaction, which were fusaridioic acid E(1), fusaridioic acid C(2), fusaridioic acid A(3), L660282(4), hymeglusin(5), and hymeglnone(6). Compound 1 is new. MTT assay and Griss method were used to evaluate the growth inhibition of all the compounds against two tumor cells, as well as their influence and anti-inflammatory action on the release of NO from LPS-induced RAW264.7 cells. The results showed that compound 5 had strong growth inhibition activity against A549 and HepG2 cell lines, with IC_(50) values of 4.70 and 13.57 μmol·L~(-1), respectively. Compounds 1 and 6 significantly inhibited the release of NO from LPS-induced RAW264.7 cells, with IC_(50) values of 77.00 and 70.33 μmol·L~(-1), respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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