Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry.

Autor: Kumar V; School of Water, Energy and Environment, Cranfield University, Cranfield, MK43 0AL, UK. Vinod.Kumar@cranfield.ac.uk.; Department of Bioscience and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India. Vinod.Kumar@cranfield.ac.uk., Kumar P; Department of Chemical Engineering, School of Studies of Engineering and Technology, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, 495009, India., Maity SK; Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Hyderabad, Telangana, 502284, India. sunil_maity@che.iith.ac.in., Agrawal D; Biochemistry and Biotechnology Area, Material Resource Efficiency Division, CSIR-Indian Institute of Petroleum, Dehradun, Uttarakhand, 248005, India., Narisetty V; School of Water, Energy and Environment, Cranfield University, Cranfield, MK43 0AL, UK., Jacob S; Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Chennai, Tamil Nadu, 603203, India., Kumar G; School of Civil and Environmental Engineering, Yonsei University, Seoul, 03722, Republic of Korea., Bhatia SK; Department of Biological Engineering, College of Engineering, Konkuk University, Seoul, 05029, Republic of Korea., Kumar D; School of Bioengineering & Food Technology, Shoolini University of Biotechnology and Management Sciences, Solan, Himachal Pradesh, 173229, India., Vivekanand V; Centre for Energy and Environment, Malaviya National Institute of Technology Jaipur, Jaipur, Rajasthan, 302017, India.
Jazyk: angličtina
Zdroj: Biotechnology for biofuels and bioproducts [Biotechnol Biofuels Bioprod] 2024 May 29; Vol. 17 (1), pp. 72. Date of Electronic Publication: 2024 May 29.
DOI: 10.1186/s13068-024-02508-2
Abstrakt: Succinic acid (SA) is one of the top platform chemicals with huge applications in diverse sectors. The presence of two carboxylic acid groups on the terminal carbon atoms makes SA a highly functional molecule that can be derivatized into a wide range of products. The biological route for SA production is a cleaner, greener, and promising technological option with huge potential to sequester the potent greenhouse gas, carbon dioxide. The recycling of renewable carbon of biomass (an indirect form of CO 2 ), along with fixing CO 2 in the form of SA, offers a carbon-negative SA manufacturing route to reduce atmospheric CO 2 load. These attractive attributes compel a paradigm shift from fossil-based to microbial SA manufacturing, as evidenced by several commercial-scale bio-SA production in the last decade. The current review article scrutinizes the existing knowledge and covers SA production by the most efficient SA producers, including several bacteria and yeast strains. The review starts with the biochemistry of the major pathways accumulating SA as an end product. It discusses the SA production from a variety of pure and crude renewable sources by native as well as engineered strains with details of pathway/metabolic, evolutionary, and process engineering approaches for enhancing TYP (titer, yield, and productivity) metrics. The review is then extended to recent progress on separation technologies to recover SA from fermentation broth. Thereafter, SA derivatization opportunities via chemo-catalysis are discussed for various high-value products, which are only a few steps away. The last two sections are devoted to the current scenario of industrial production of bio-SA and associated challenges, along with the author's perspective.
(© 2024. The Author(s).)
Databáze: MEDLINE
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