The full genome characterization of avian encephalomyelitis virus, Iran: a vertical transmission case.

Autor: Ghalyanchilangeroudi A; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Madani SA; Department of Animal and Poultry Health and Nutrition, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Najafi H; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Ziafati Kafi Z; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Sadri N; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Sarmadi S; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Eghbali O; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Jamiri F; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Bakhshi A; Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran., Hosseini H; Department of Clinical Sciences, Faculty of Veterinary Medicine, Karaj Branch, Islamic Azad University, Alborz, Iran. hosseini.ho@gmail.com.
Jazyk: angličtina
Zdroj: Virus genes [Virus Genes] 2024 Aug; Vol. 60 (4), pp. 393-401. Date of Electronic Publication: 2024 May 29.
DOI: 10.1007/s11262-024-02076-5
Abstrakt: Avian encephalomyelitis (AE) is an important infectious poultry disease worldwide that is caused by avian encephalomyelitis virus (AEV). The causative virus can be transmitted both horizontally and vertically. In the present study, an AEV suspected outbreak with typical neurological signs occurred in broilers. Histopathological examination, RT-PCR assay and full genome sequencing were applied to confirm the presence of AEV. Phylogenetic analysis of the full genome sequence showed that the detected AEV strain at 7055 nucleotide length is classified in cluster I and is closely related to vaccinal USA and China originated isolates. Although, the outbreaks of AE in progeny of vaccinated breeders have been reported previously, the source of infection was unknown. Based on the results obtained in this study, the outbreaks are vaccine-originated. This study provides the first whole genome analysis of AEV from Iran and reveals that the AEV possesses a hepatitis C virus-like internal ribosome entry site.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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