Platelet-rich plasma therapy in erectile dysfunction and Peyronie's disease: a systematic review of the literature.

Autor: Asmundo MG; Urology Section, University of Catania, Catania, Italy., Durukan E; Department of Urology, Copenhagen University Hospital - Herlev and Gentofte, University of Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., von Rohden E; Department of Urology, Copenhagen University Hospital - Herlev and Gentofte, University of Copenhagen, Herlev, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Thy SA; Department of Urology, Copenhagen University Hospital - Herlev and Gentofte, University of Copenhagen, Herlev, Denmark., Jensen CFS; Department of Urology, Copenhagen University Hospital - Herlev and Gentofte, University of Copenhagen, Herlev, Denmark., Fode M; Department of Urology, Copenhagen University Hospital - Herlev and Gentofte, University of Copenhagen, Herlev, Denmark. mikkel.mejlgaard.fode@regionh.dk.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. mikkel.mejlgaard.fode@regionh.dk.
Jazyk: angličtina
Zdroj: World journal of urology [World J Urol] 2024 May 29; Vol. 42 (1), pp. 359. Date of Electronic Publication: 2024 May 29.
DOI: 10.1007/s00345-024-05065-3
Abstrakt: Purpose: Platelet-rich plasma (PRP) as a regenerative therapy has gained interest in the field of andrology for the treatment of erectile dysfunction (ED) and Peyronie's disease (PD). This systematic review aims to critically evaluate the current evidence on the use of PRP for these conditions.
Methods: We performed a systematic literature search according to the PRISMA guidelines using PubMed and Scopus databases in December 2023. Studies were included if they evaluated the effect of PRP therapy for ED or PD in humans.
Results: We identified 164 articles, 17 of which were included, consisting of 11 studies on ED, 5 studies on PD, and 1 study on both. We included four randomized controlled trials, 11 prospective cohort studies, and three retrospective cohort studies including a total of 1099 patients. The studies on ED and PD generally showed small to moderate benefits with mild and transient side effects and no major adverse events were reported. General limitations included variations in PRP protocols, small sample sizes, short follow-up periods, and lack of control groups except in the three randomized trials on ED and the one on PD.
Conclusion: The literature on PRP therapy in andrology is limited and difficult to interpret due to variations in protocols and methodological drawbacks. Further research is necessary to determine the optimal preparation and treatment protocols for PRP therapy and clarify its effectiveness in andrology.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: