Decoding microtubule detyrosination: enzyme families, structures, and functional implications.

Autor: Bak J; Oncode Institute and Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands., Brummelkamp TR; Oncode Institute and Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands., Perrakis A; Oncode Institute and Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2024 Jun; Vol. 598 (12), pp. 1453-1464. Date of Electronic Publication: 2024 May 29.
DOI: 10.1002/1873-3468.14940
Abstrakt: Microtubules are a major component of the cytoskeleton and can accumulate a plethora of modifications. The microtubule detyrosination cycle is one of these modifications; it involves the enzymatic removal of the C-terminal tyrosine of α-tubulin on assembled microtubules and the re-ligation of tyrosine on detyrosinated tubulin dimers. This modification cycle has been implicated in cardiac disease, neuronal development, and mitotic defects. The vasohibin and microtubule-associated tyrosine carboxypeptidase enzyme families are responsible for microtubule detyrosination. Their long-sought discovery allows to review and summarise differences and similarities between the two enzymes families and discuss how they interplay with other modifications and functions of the tubulin code.
(© 2024 The Author(s). FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.)
Databáze: MEDLINE
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