Neuronal Subtypes and Connectivity of the Adult Mouse Paralaminar Amygdala.

Autor:	Saxon D; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC 20011 jcorbin@childrensnational.org.; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20007., Alderman PJ; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260., Sorrells SF; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260., Vicini S; Interdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, DC 20007.; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20007., Corbin JG; Center for Neuroscience Research, Children's Research Institute, Children's National Hospital, Washington, DC 20011 jcorbin@childrensnational.org.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2024 Jun 18; Vol. 11 (6). Date of Electronic Publication: 2024 Jun 18 (Print Publication: 2024).
DOI:	10.1523/ENEURO.0119-24.2024
Abstrakt:	The paralaminar nucleus of the amygdala (PL) comprises neurons that exhibit delayed maturation. PL neurons are born during gestation but mature during adolescent ages, differentiating into excitatory neurons. These late-maturing PL neurons contribute to the increase in size and cell number of the amygdala between birth and adulthood. However, the function of the PL upon maturation is unknown, as the region has only recently begun to be characterized in detail. In this study, we investigated key defining features of the adult mouse PL; the intrinsic morpho-electric properties of its neurons, and its input and output circuit connectivity. We identify two subtypes of excitatory neurons in the PL based on unsupervised clustering of electrophysiological properties. These subtypes are defined by differential action potential firing properties and dendritic architecture, suggesting divergent functional roles. We further uncover major axonal inputs to the adult PL from the main olfactory network and basolateral amygdala. We also find that axonal outputs from the PL project reciprocally to these inputs and to diverse targets including the amygdala, frontal cortex, hippocampus, hypothalamus, and brainstem. Thus, the adult mouse PL is centrally placed to play a major role in the integration of olfactory sensory information, to coordinate affective and autonomic behavioral responses to salient odor stimuli. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Saxon et al.)
Databáze:	MEDLINE
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