| Autor: |
Chu D; Department of Chemistry, Yale University, New Haven, Connecticut 04720, United States., Zoll AJ; Department of Chemistry, Yale University, New Haven, Connecticut 04720, United States., Ellman JA; Department of Chemistry, Yale University, New Haven, Connecticut 04720, United States. |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2024 Jun 07; Vol. 26 (22), pp. 4803-4807. Date of Electronic Publication: 2024 May 29. |
| DOI: |
10.1021/acs.orglett.4c01634 |
| Abstrakt: |
Unprotected, highly substituted morpholines were obtained through a copper-catalyzed three-component reaction utilizing amino alcohols, aldehydes, and diazomalonates. The transformation was effective for diversely substituted aldehydes and for a broad range of readily available vicinal amino alcohols, including those derived from glycine, α-substituted, and α,α-disubstituted amino acids. Epimerization of morpholines using light-mediated stereochemical editing was demonstrated, and the unprotected morpholine products were readily elaborated through efficient transformations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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