Multiscale engineering of brain organoids for disease modeling.

Autor: Xu C; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA., Alameri A; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA., Leong W; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA., Johnson E; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA., Chen Z; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA., Xu B; Department of Psychiatry, Columbia University, New York, NY 10032, USA. Electronic address: bx2105@cumc.columbia.edu., Leong KW; Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA. Electronic address: kamleong1@gmail.com.
Jazyk: angličtina
Zdroj: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2024 Jul; Vol. 210, pp. 115344. Date of Electronic Publication: 2024 May 27.
DOI: 10.1016/j.addr.2024.115344
Abstrakt: Brain organoids hold great potential for modeling human brain development and pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular diversity, tissue architecture and functions of the developing brain. In this review, we explore the engineering strategies to control the molecular-, cellular- and tissue-level inputs to achieve high-fidelity brain organoids. We review the application of brain organoids in neural disorder modeling and emerging bioengineering methods to improve data collection and feature extraction at multiscale. The integration of multiscale engineering strategies and analytical methods has significant potential to advance insight into neurological disorders and accelerate drug development.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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