Cardiac Reverse Remodeling Mediated by HeartMate 3 Left Ventricular Assist Device: Comparison to Older Generation Devices.

Autor:	Yin MY; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Maneta E; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Kyriakopoulos CP; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Michaels AT; Division of Cardiology and Cardiothoracic Surgery, Henry Ford Hospital, Detroit, Michigan., Genovese LD; Division of Cardiology and Cardiothoracic Surgery, Inova Heart and Vascular Institute, Falls Church, Virginia., Indaram MB; Division of Cardiology and Cardiothoracic Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania., Wever-Pinzon O; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Singh R; Division of Cardiology and Cardiothoracic Surgery, Inova Heart and Vascular Institute, Falls Church, Virginia., Tseliou E; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Taleb I; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Nemeh HW; Division of Cardiology and Cardiothoracic Surgery, Henry Ford Hospital, Detroit, Michigan., Alharethi R; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Tang DG; Division of Cardiology and Cardiothoracic Surgery, Inova Heart and Vascular Institute, Falls Church, Virginia., Goldstein J; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Hanff TC; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Selzman CH; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah., Cowger J; Division of Cardiology and Cardiothoracic Surgery, Henry Ford Hospital, Detroit, Michigan., Kanwar M; Division of Cardiology and Cardiothoracic Surgery, Allegheny Health Network, Pittsburgh, Pennsylvania., Shah P; Division of Cardiology and Cardiothoracic Surgery, Inova Heart and Vascular Institute, Falls Church, Virginia., Drakos SG; From the Utah Cardiac Recovery (UCAR) Program (Divisions of Cardiology and Cardiothoracic Surgery at University of Utah Health & School of Medicine, Intermountain Medical Center, and George E. Wahlen Department of Veterans Affairs Medical Center), Salt Lake City, Utah.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2024 Dec 01; Vol. 70 (12), pp. 1060-1066. Date of Electronic Publication: 2024 May 28.
DOI:	10.1097/MAT.0000000000002245
Abstrakt:	Currently, the fully magnetically levitated left ventricular assist device (LVAD) HeartMate 3 (HM3) is the only commercially available device for advanced heart failure (HF) patients. However, the left ventricular (LV) functional and structural changes following mechanical unloading and circulatory support (MCS) with the HM3 have not been investigated. We compared the reverse remodeling induced by the HM3 to older generation continuous-flow LVADs. Chronic HF patients (n = 405) undergoing MCS with HeartWare Ventricular Assist Device (HVAD, n = 115), HM3 (n = 186), and HeartMate II (HM2, n = 104) at four programs were included. Echocardiograms were obtained preimplant and at 1, 3, 6, and 12 months following LVAD implantation. There were no differences in the postimplant serial LV ejection fraction (LVEF) between the devices. The postimplant LV internal diastolic diameter (LVIDd) was significantly lower for HM2 at 3 and 6 months compared with HVAD and HM3. The proportion of patients achieving "cardiac reverse remodeling responder" status (defined as LVEF improvement to ≥40% and LVIDD ≤5.9 cm) was 11.9%, and was similar between devices. HeartMate 3 appears to result in similar cardiac reverse remodeling as older generation CF-LVADs, suggesting that the fully magnetically levitated device technology could provide an effective platform to further study and promote cardiac reverse remodeling. Competing Interests: S.G.D. serves as a consultant for Abbott Laboratoriesand has received research support from Novartis. The other authors have no conflicts of interest to report. (Copyright © ASAIO 2024.)
Databáze:	MEDLINE
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