[The influence of diet therapy and regular physical trainings on monocyte chemoattractant protein-1 (MCP-1) secretion by monocytes among obese patients with coronary heart disease].

Autor:	Starodubova AV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.; Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, 129226, Moscow, Russian Federation., Shaposhnikova NN; Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation., Varaeva YR; Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation., Kirichenko TV; Petrovsky National Research Center of Surgery, 119991, Moscow, Russian Federation., Markina YV; Petrovsky National Research Center of Surgery, 119991, Moscow, Russian Federation., Tolstik TV; Petrovsky National Research Center of Surgery, 119991, Moscow, Russian Federation., Nikityuk DV; Federal Research Centre of Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
Jazyk:	ruština
Zdroj:	Voprosy pitaniia [Vopr Pitan] 2024; Vol. 93 (2), pp. 63-72. Date of Electronic Publication: 2024 Feb 01.
DOI:	10.33029/0042-8833-2024-93-2-63-72
Abstrakt:	Chronic systemic inflammation is one of the leading pathogenetic pathways for the development of atherosclerosis in obese patients. In this regard, it seems promising to evaluate the effect of the diet and physical exertion on the proinflammatory activity of monocytes. The purpose of this research was to evaluate the effect of the diet and regular physical trainings on the secretion of monocyte chemotactic factor 1 (MCP-1) by monocytes in obese patients with coronary artery disease. Material and methods . 27 obese participants (body mass index >30 kg/m2) with a confirmed diagnosis of coronary heart disease were recruited. All participants were prescribed with 12 weeks of a specialized diet with a restriction of simple carbohydrates and salt, a 500-kcal daily energy deficit, and with inclusion of cruciferous (200 g per day), seasonal dark berries (70 g per day) and green tea (200 ml per day). The regular assisted physical trainings were also administered. The body composition, blood biochemical parameters and MCP-1 secretion rates in the primary culture of monocytes isolated from blood samples via the immunomagnetic separation method were assessed before and after the intervention. Results . As a result, after the 12-weeks intervention the reliable body weight loss (-4.0%), waist circumference (-4.2%), visceral fat (-5.4%), total cholesterol (-9.8%), LDL-cholesterol (-16.6%) and triglycerides (-26.0%), an improvement in the results of the 6-minute walk test (+10.33%) was achieved, as well as an LPS-stimulated monocytes secretion of MCP-1 decreased by 2.8 times (p=0.005). Conclusion . Overall, the results suggest that diet and regular physical activity in patients with obesity and coronary heart disease may decrease the functional "proinflammatory" activity of monocytes. Competing Interests: The authors declare no conflicts of interest. (Copyright© GEOTAR-Media Publishing Group.)
Databáze:	MEDLINE
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