Relationship between skeletal mitochondrial function and digital markers of free-living physical activity in older adults.

Autor: Wanigatunga AA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. awaniga1@jhu.edu.; Center On Aging and Health, Johns Hopkins University and Medical Institutions, Baltimore, MD, USA. awaniga1@jhu.edu.; Baltimore, MD, 21025, USA. awaniga1@jhu.edu., Liu F; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Dougherty RJ; Center On Aging and Health, Johns Hopkins University and Medical Institutions, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA., Roche KB; Center On Aging and Health, Johns Hopkins University and Medical Institutions, Baltimore, MD, USA.; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Urbanek JK; Center On Aging and Health, Johns Hopkins University and Medical Institutions, Baltimore, MD, USA.; Biostatistics and Data Management, Regeneron Pharmaceuticals, Tarrytown, NY, USA., Zampino M; Department of Internal Medicine, University of Maryland, Baltimore, MD, USA., Simonsick EM; Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA., Tian Q; Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA., Schrack JA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Center On Aging and Health, Johns Hopkins University and Medical Institutions, Baltimore, MD, USA., Ferrucci L; Intramural Research Program, National Institute On Aging, National Institutes of Health, Baltimore, MD, USA.
Jazyk: angličtina
Zdroj: GeroScience [Geroscience] 2024 Dec; Vol. 46 (6), pp. 6173-6182. Date of Electronic Publication: 2024 May 29.
DOI: 10.1007/s11357-024-01212-1
Abstrakt: This study examined the association between in vivo skeletal mitochondrial function and digital free-living physical activity patterns-a measure that summarizes biological, phenotypic, functional, and environmental effects on mobility. Among 459 participants (mean age 68 years; 55% women) in the Baltimore Longitudinal Study of Aging, mitochondrial function was quantified as skeletal muscle oxidative capacity via post-exercise phosphocreatine recovery rate (τ PCr ) in the vastus lateralis muscle of the left thigh, using 31P magnetic resonance spectroscopy. Accelerometry was collected using a 7-day, 24-h wrist-worn protocol and summarized into activity amount, intensity, endurance, and accumulation patterning metrics. Linear regression, two-part linear and logistic (bout analyses), and linear mixed effects models (time-of-day analyses) were used to estimate associations between τ PCr and each physical activity metric. Interactions by age, sex, and gait speed were tested. After covariate adjustment, higher τ PCr (or poorer mitochondrial function) was associated with lower activity counts/day (β =  - 6593.7, SE = 2406.0; p = 0.006) and activity intensity (- 81.5 counts, SE = 12.9; p < 0.001). For activity intensity, the magnitude of association was greater for men and those with slower gait speed (interaction p < 0.02 for both). Conversely, τ PCr was not associated with daily active minutes/day (p = 0.15), activity fragmentation (p = 0.13), or endurance at any bout length (p > 0.05 for all). Time-of-day analyses show participants with high τ PCr were less active from 6:00 a.m. to 12:00 a.m. than those with low τ PCr . Results indicate that poorer skeletal mitochondrial function is primarily associated with lower engagement in high intensity activities. Our findings help define the connection between laboratory-measured mitochondrial function and real-world physical activity behavior.
(© 2024. The Author(s), under exclusive licence to American Aging Association.)
Databáze: MEDLINE
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