Nasal and Pharyngeal Mucosal Immunity to Poliovirus in Children Following Routine Immunization With Inactivated Polio Vaccine in the United States.

Autor:	Godin A; Health Equity Action Lab, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Connor RI; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA., Degefu HN; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA., Rosato PC; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA., Wieland-Alter WF; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA., Axelrod KS; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA., Kovacikova G; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA., Weiner JA; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA., Ackerman ME; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.; Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA., Chen EY; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA.; Department of Surgery, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA., Arita M; Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan., Bandyopadhyay AS; Polio, Global Development, Bill & Melinda Gates Foundation, Seattle, Washington, USA., Raja AI; Health Equity Action Lab, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Modlin JF; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA., Brickley EB; Health Equity Action Lab, Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Wright PF; Department of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Health, Lebanon, New Hampshire, USA.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Nov 15; Vol. 230 (5), pp. e1023-e1030.
DOI:	10.1093/infdis/jiae264
Abstrakt:	Background: Although polioviruses (PVs) replicate in lymphoid tissue of both the pharynx and ileum, research on polio vaccine-induced mucosal immunity has predominantly focused on intestinal neutralizing and binding antibody levels measured in stool. Methods: To investigate the extent to which routine immunization with intramuscularly injected inactivated polio vaccine (IPV) may induce nasal and pharyngeal mucosal immunity, we measured PV type-specific neutralization and immunoglobulin (Ig) G, IgA, and IgM levels in nasal secretions, adenoid cell supernatants, and sera collected from 12 children, aged 2-5 years, undergoing planned adenoidectomies. All participants were routinely immunized with IPV and had no known contact with live PVs. Results: PV-specific mucosal neutralization was detected in nasal and adenoid samples, mostly from children who had previously received 4 IPV doses. Across the 3 PV serotypes, both nasal (Spearman ρ ≥ 0.87, P ≤ .0003 for all) and adenoid (Spearman ρ ≥ 0.57, P ≤ .05 for all) neutralization titers correlated with serum neutralization titers. In this small study sample, there was insufficient evidence to determine which Ig isotype(s) was correlated with neutralization. Conclusions: Our findings provide policy-relevant evidence that routine immunization with IPV may induce nasal and pharyngeal mucosal immunity. The observed correlations of nasal and pharyngeal mucosal neutralization with serum neutralization contrast with previous observations of distinct intestinal and serum responses to PV vaccines. Further research is warranted to determine which antibody isotype(s) correlate with polio vaccine-induced nasal and pharyngeal mucosal neutralizing activity and to understand the differences from intestinal mucosal immunity. Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
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