Foveal thickness and its association with visual acuity in adults born preterm with very low birth weight: A two-country birth cohort study.

Autor: Jørgensen APM; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Kulmala M; Public Health Unit, Finnish Institute for Health and Welfare, Helsinki/Oulu, Finland.; Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland., Austeng D; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Ophthalmology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Evensen KAI; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.; Children's Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.; Department of Rehabilitation Science and Health Technology, Oslo Metropolitan University, Oslo, Norway., Kajantie E; Public Health Unit, Finnish Institute for Health and Welfare, Helsinki/Oulu, Finland.; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.; Clinical Medicine Research Unit, Oulu University Hospital, University of Oulu, Oulu, Finland.; Children's Hospital, Helsinki University Hospital, Helsinki, Finland.; University of Helsinki, Helsinki, Finland., Majander A; Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.; University of Helsinki, Helsinki, Finland., Morken TS; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Ophthalmology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Acta ophthalmologica [Acta Ophthalmol] 2024 May 29. Date of Electronic Publication: 2024 May 29.
DOI: 10.1111/aos.16725
Abstrakt: Purpose: To explore foveal and parafoveal thickness in adults born preterm with very low birth weight (VLBW) and its association with best-corrected visual acuity (BCVA) and gestational age (GA) compared to adults born at term.
Methods: In a joint study of the Helsinki Study of Very Low Birth Weight Adults (Finland) and the NTNU Low Birth Weight Life study (Norway), 106 VLBW and 143 term-born controls were examined with spectral-domain optical coherence tomography and BCVA at age 31-43 years. Thickness of retinal layers was segmented in the foveal and parafoveal areas of the macula.
Results: The total retinal thickness in the foveal area was thicker in VLBW adults compared with controls; mean (SD): 292.5 μm (28.2) and 272.4 μm (20.2); p < 0.001, and thinner in the parafoveal areas of the macula. These findings could be explained by a thicker inner retinal layer in the foveal area found in VLBW adults compared with controls (mean difference 20.4 μm; CI: 15.0 to 25.9), where a thicker fovea was associated with lower GA, but not BCVA.
Conclusion: Adults born preterm with VLBW had a thicker retina in the foveal area than controls and this was associated with GA, but not with BCVA. These changes seem to be related to a thicker inner retinal layer in VLBW adults. The findings imply that signs of macular underdevelopment are still present in adulthood, but not necessarily related to reduced visual function.
(© 2024 The Author(s). Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
Databáze: MEDLINE
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