Treatment-emergent cefiderocol resistance in carbapenem-resistant Acinetobacter baumannii is associated with insertion sequence IS Aba36 in the siderophore receptor pirA .

Autor: Huang E; Department of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Thompson RN; Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Moon SH; Department of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Keck JM; Department of Pharmacy Practice, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Lowry MS; Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Melero J; Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Jun S-R; Department of Biomedical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Rosenbaum ER; Department of Pathology and Laboratory Services, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA., Dare RK; Department of Internal Medicine, Division of Infectious Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Jul 09; Vol. 68 (7), pp. e0029024. Date of Electronic Publication: 2024 May 29.
DOI: 10.1128/aac.00290-24
Abstrakt: We report the emergence of cefiderocol resistance in a bla OXA-72 carbapenem-resistant Acinetobacter baumannii isolate from a sacral decubitus ulcer. Cefiderocol was initially used; however, a newly approved sulbactam-durlobactam therapy with source control and flap coverage was successful in treating the infection. Laboratory investigation revealed cefiderocol resistance mediated by IS Aba36 insertion into the siderophore receptor pirA .
Competing Interests: The authors declare no conflict of interest.
Databáze: MEDLINE