Higher expression of SALL4-A isoform is correlated with worse outcomes and progression of the disease in subtype of testicular germ cell tumours.
| Autor: | Lakpour N; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Ghods R; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran., Abolhasani M; Department of Pathology, School of Medicine, Iran University of Medical Sciences, (IUMS), Tehran, Iran., Saeednejad Zanjani L; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Pathology and Genomic Medicine, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Saliminejad K; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Kalantari E; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran., Saki S; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran., Ranjbar MM; Department of Immunology, Razi Vaccine and Sera Research Institute, Karaj, Iran., Balay-Goli L; Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Sadeghi MR; Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran., Madjd Z; Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.; Department of Pathology, School of Medicine, Iran University of Medical Sciences, (IUMS), Tehran, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2024 Jul; Vol. 29 (5), pp. 324-339. Date of Electronic Publication: 2024 Jun 05. |
| DOI: | 10.1080/1354750X.2024.2361796 |
| Abstrakt: | Background: The transcription factor SALL4 is associated with embryonic pluripotency and has proposed as a novel immunohistochemistry (IHC) marker for diagnosing germ cell tumours. SALL4 comprises three isoforms, and SALL4-A being the full-length isoform. Studying its isoforms could revolutionize testicular cancer prognosis and subtype differentiation. Methods: The expression and clinical significance of isoform 'A' of SALL4 was evaluated in 124 testicular germ cell tumours (TGCTs) subtypes, adjacent 67 normal tissues and 22 benign tumours, using immunohistochemistry on tissue microarrays (TMA). Results: A statistically significant higher expression of nuclear and cytoplasmic SALL4-A was detected in TGCTs histological subtypes and benign tumours compared to the normal tissues. Seminoma and yolk sac tumours had the highest nuclear and cytoplasmic expression of SALL4-A. A significant correlation was detected between the higher nuclear expression of SALL4-A and increased pT stages ( P = 0.026) in seminomas. Whereas in embryonal carcinomas, cytoplasmic expression of SALL4-A was associated with the tumour recurrence ( P = 0.04) and invasion of the epididymis ( P = 0.011). Conclusions: SALL4-A isoform expression in the cytoplasm and nucleus of TGCTs may be associated with histological differentiation. In the seminoma subtype of TGCTs, higher expression of SALL4-A may be used as a predictive indicator of poorer outcomes and prognosis. |
| Databáze: | MEDLINE |
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