Ethyl acetate in e-liquids: Implications for breath testing.

Autor:	Holt AK; Department of Forensic Science, Virginia Commonwealth University, 1015 West Main Street, Room 2015, Richmond, VA 23284, United States.; Integrative Life Sciences Doctoral Program, Virginia Commonwealth University, PO Box 842030, Richmond, VA 23284, United States., Veeser AM; Department of Forensic Science, Virginia Commonwealth University, 1015 West Main Street, Room 2015, Richmond, VA 23284, United States., Poklis JL; Department of Pharmacology and Toxicology, Virginia Commonwealth University, 112 East Clay Street, PO Box 980613, Richmond, VA 23298, United States., Peace MR; Department of Forensic Science, Virginia Commonwealth University, 1015 West Main Street, Room 2015, Richmond, VA 23284, United States.
Jazyk:	angličtina
Zdroj:	Journal of analytical toxicology [J Anal Toxicol] 2024 Jul 13; Vol. 48 (6), pp. 413-418.
DOI:	10.1093/jat/bkae044
Abstrakt:	Electronic cigarette liquids (e-liquids) can contain a variety of chemicals to impart flavors, smells and pharmacological effects. Surveillance studies have identified hundreds of chemicals used in e-liquids that have known health and safety implications. Ethyl acetate has been identified as a common constituent of e-liquids. Ethyl acetate is rapidly hydrolyzed to ethanol in vivo. Animal studies have demonstrated that inhaling >2,000 mg/L ethyl acetate can lead to the accumulation of ethanol in the blood at concentrations >1,000 mg/L, or 0.10%. A "Heisenberg" e-liquid was submitted to the Laboratory for Forensic Toxicology Research for analysis after a random workplace drug test resulted in a breath test result of 0.019% for a safety-sensitive position employee. Analysis of this sample resulted in the detection of 1,488 ± 6 mg/L ethyl acetate. The evaluation of purchased "Heisenberg" e-liquids determined that these products contain ethyl acetate. The identification of ethyl acetate in e-liquids demonstrates poor regulatory oversight and enforcement that potentially has consequences for breath ethanol testing and interpretations. The accumulation of ethanol in the breath from the ingestion/inhalation of ethyl acetate from an e-liquid used prior to a breath test may contribute to the detection of ethanol. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site–for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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